Basic Informations of Caspase-3

Entrez Gene ID: 12367 [Pubmed]

UniProt Protein Name: Caspase-3

UniProt ID: P70677

Related Drug:

DrugBank IDDrug Name
DB08498"(1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate"
DB08497"(1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate"
DB07696methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate
DB031245-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid


PMID:20026776|Circulation. 2010; 121: 80-90
..."Furthermore, tumor necrosis factor-alpha, interleukin-1alpha, granulocyte macrophage colony-stimulating factor, and interleukin-10 were significantly reduced, as were phosphorylated c-jun N-terminal kinase, phosphorylated p38 mitogen-activated protein kinase, and caspase 3/7 activity levels."...

PMID:20625112|Circulation. 2010;122:361-369
..."In the hearts of WT mice, CHOP-increased apoptotic cell death with activation of caspase-3 was observed at 4 weeks after transverse aortic constriction."...

PMID:21060073|Circulation. 2010;122:2170-2182
..."Sirt1 positively regulates expression of prosurvival molecules, including manganese superoxide dismutase, thioredoxin-1, and Bcl-xL, whereas it negatively regulates the proapoptotic molecules Bax and cleaved caspase-3. "...

PMID:19433762|Circulation. 2009;119:2686-2692
...This correlated with decreased staining of proliferating cell nuclear antigen-positive cells and increased staining of cleaved caspase-3 in the intima of N1(+/-)- or smN1+/- mice. ...

PMID:19652095|Circulation. 2009;120:617-627
...RGC-32 also stimulated apoptosis as shown by the increased apoptotic cells and caspase-3 cleavage. ...

[All Refs in Pubmed]

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