Basic Informations of C-X-C chemokine receptor type 4

Entrez Gene ID: 12767 [Pubmed]

UniProt Protein Name: C-X-C chemokine receptor type 4

UniProt ID: P70658


Related Drug:

DrugBank IDDrug Name
DB06809Plerixafor
DB00452Framycetin

References

PMID:17646584|Circulation. 2007;116:654-663
..."In isolated myocytes, CXCR4 activation by SDF-1alpha resulted in increased phosphorylation of both ERK 1/2 and AKT and decreased phosphorylation of JNK and p38"...

PMID:18086932|Circulation. 2008;117:206-215
..."Moreover, platelet-derived SDF-1 binding to CXCR4 receptor promotes platelet-induced differentiation of CD34+ cells into endothelial progenitor cells, as verified by colony-forming assays in vitro."...

PMID:18427137|Circulation. 2008;117:2224-2231
..."Here we show that the secreted signaling protein stromal cell-derived factor-1alpha (SDF-1alpha), which activates the cell-survival factor protein kinase B (PKB/Akt) via the G protein-coupled receptor CXCR4, protected tissue after an acute ischemic event in mice and activated Akt within endothelial cells and myocytes of the heart. "...

[All Refs in Pubmed]



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