Basic Informations of CX3C chemokine receptor 1

Entrez Gene ID: 13051 [Pubmed]

UniProt Protein Name: CX3C chemokine receptor 1

UniProt ID: Q9Z0D9

Related Drug:

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PMID:17679613|Circulation. 2007;116:764-773
..."In the presence of high shear, firm adhesion of leukocytes to inflamed endothelial cells is reduced by approximately 40% by a function-blocking anti-fractalkine antibody or by an antibody directed against the fractalkine receptor (CX3CR1). "...

PMID:18165355|Circulation. 2008;117:1642-1648
..." Genetic deletions of monocyte chemoattractant protein-1 (MCP-1, CCL2), fractalkine (CX3CL1), or their cognate receptors, CCR2 and CX3CR1, markedly reduce atherosclerotic lesion size in murine models of atherosclerosis. "...

PMID:18347211|Circulation. 2008;117:1649-1657
..."CCL2, CX3CR1, and CCR5 play independent and additive roles in atherogenesis. Signals mediated through these pathways critically determine the frequency of circulating monocyte subsets and thereby account for almost all macrophage accumulation into atherosclerotic arteries."...

[All Refs in Pubmed]

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