Basic Informations of Estrogen receptor

Entrez Gene ID: 13982 [Pubmed]

UniProt Protein Name: Estrogen receptor

UniProt ID: P19785


Related Drug:

DrugBank IDDrug Name
DB08773RALOXIFENE CORE
DB08737"(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL"
DB08595"4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL"
DB08398"2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE"
DB08320"DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE"
DB08048"4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL"
DB08047"4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol"
DB08020"(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL"
DB07991N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE
DB07933"(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL"
DB07932"dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate"
DB077123-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
DB077083-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
DB07707"(9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL"
DB07678"(9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL"
DB07638"(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL"
DB07567"(2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL"
DB07195"4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL"
DB07087"4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL"
DB07086"4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL"
DB06927[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE
DB06898"4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol"
DB0687117-METHYL-17-ALPHA-DIHYDROEQUILENIN
DB06713Norelgestromin
DB04575Quinestrol
DB04574Estropipate
DB04573Estriol
DB04471"2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol"
DB03802"1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol"
DB03742Compound 4-D
DB02715Compound 18
DB02615Compound 19
DB01645Genistein
DB01431Allylestrenol
DB01406Danazol
DB01357Mestranol
DB01196Estramustine
DB01185Fluoxymesterone
DB01183Naloxone
DB01108Trilostane
DB01065Melatonin
DB00977Ethinyl Estradiol
DB00957Norgestimate
DB00947Fulvestrant
DB00890Dienestrol
DB00882Clomifene
DB00823Ethynodiol Diacetate
DB00783Estradiol
DB00675Tamoxifen
DB00655Estrone
DB00603Medroxyprogesterone
DB00539Toremifene
DB00481Raloxifene
DB00396Progesterone
DB00367Levonorgestrel
DB00304Desogestrel
DB00294Etonogestrel
DB00286Conjugated Estrogens
DB00269Chlorotrianisene
DB00255Diethylstilbestrol

References

PMID:17088460|Circulation. 2006;114:2261-2270
...Both ER alpha and ER beta contribute to E2-mediated EPC activation and tissue incorporation and to preservation of cardiac function after myocardial infarction....

PMID:17562954|Circulation. 2007;115:3197-3204
..."These antiapoptotic and cardioprotective effects of E2 were blocked by an estrogen receptor antagonist (ICI 182,780) and by a Trx reductase inhibitor (azelaic acid)."...

PMID:|Circulation. 2009;120:2567-2576
..."We demonstrate directly and for the first time that endothelial ERalpha represents a key target of the atheroprotective effect of estradiol, whereas hematopoietic ERalpha is dispensable. Selective estrogen receptor modulators that mimic the endothelial action of estradiol should now be considered in atheroprotection."...

[All Refs in Pubmed]



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