Basic Informations of GTP cyclohydrolase 1

Entrez Gene ID: 14528 [Pubmed]

UniProt Protein Name: GTP cyclohydrolase 1

UniProt ID: Q05915


Related Drug:

DrugBank IDDrug Name
DB04137Guanosine-5'-Triphosphate
DB02377Guanine

References

PMID:18268143|Circulation. 2008;117:1045-1054
..."These results demonstrate that endothelium-specific GTPCH I overexpression abrogates O2(-) production and preserves eNOS phosphorylation, which results in preserved structural and functional integrity of resistance mesenteric arteries and lowered blood pressure in low-renin hypertension."...

PMID:18824773|Circulation. 2008;118[suppl 1]:S71–S77
..."Endothelium-targeted overexpression of GTP cyclohydrolase 1 (GCH), the rate limiting enzyme in BH4 synthesis, increased levels of tetrahydrobiopterin (BH4), reduced endothelial superoxide, improved eNOS coupling, and reduced vein graft atherosclerosis in transgenic GCH/ApoE-KO mice compared to ApoE-KO controls. "...

[All Refs in Pubmed]



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