Basic Informations of Guanine nucleotide-binding protein G(q) subunit alpha

Entrez Gene ID: 14682 [Pubmed]

UniProt Protein Name: Guanine nucleotide-binding protein G(q) subunit alpha

UniProt ID: P21279


Related Drug:

No Related Drugs

References

PMID:16380548|Circulation. 2006;113:60-66
...These results demonstrated the first evidence that DGKzeta negatively regulated the hypertrophic signaling cascade and resultant cardiac hypertrophy in response to GPCR agonists without detectable adverse effects in in vivo hearts...

PMID:21747049|Circulation. 2011;124:572-581
..."Because the V1A receptor mediates cell signaling through Gα(q) protein, we blocked Gα(q) signaling by crossing tetracycline-transactivating factor/V1A mice with transgenic mice that expressed a small inhibitory peptide against Gα(q). "...

PMID:18443239|Circulation. 2008;117:2329-2339
..."These results provide evidence that GC-A activates cardiac RGS4, which attenuates Galpha(q) and its downstream hypertrophic signaling, and that RGS4 plays important roles in GC-A-mediated inhibition of cardiac hypertrophy."...

[All Refs in Pubmed]



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