Basic Informations of Interleukin-1 beta

Entrez Gene ID: 16176 [Pubmed]

UniProt Protein Name: Interleukin-1 beta

UniProt ID: P10749


Related Drug:

DrugBank IDDrug Name
DB06168Canakinumab
DB05260Gallium nitrate
DB01017Minocycline

References

PMID:16820587|Circulation. 2006;114[suppl I]:I-282–I-289
..."Interestingly, TNFR1 ablation improved postischemic myocardial function, decreased activation of p38 mitogen-activated protein kinase, and reduced expression of interleukins-1beta and -6 in males but not in females."...

PMID:20421523|Circulation. 2010;121:2023-2032
..."The tumor necrosis factor-alpha-induced proinflammatory response of SMCs is inhibited by Nurr1, as reflected by reduced interleukin-1beta, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1 expression."...

PMID:18332263|Circulation. 2008;117:1574-1582
..."Myocardial interferon-beta1, interferon-gamma, interleukin-6, interleukin-10, and macrophage inflammatory protein-1alpha expression was elevated in MMP-9 KO mice as measured by quantitative real-time polymerase chain reaction and ELISA."...

PMID:18541743|Circulation. 2008;117: 3079-3087
...Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is an adaptor protein that regulates caspase-1-dependent IL-1 beta and IL-18 generation; ...

PMID:18824767|Circulation. 2008;118[suppl 1]:S38–S45
..."The deleterious effects of TNFR2 ablation were associated with a decrease in mRNA and protein levels of SOCS3, STAT3, and vascular endothelial growth factor as well as an increase in myocardial interleukin-1-beta production in female hearts. "...

PMID:19255345|Circulation. 2009;119:1386-1397
..."Compared with sham, WT HF hearts exhibited significant remodeling with robust activation of nuclear factor (NF)-kappaB, p38 mitogen-activated protein kinase, and JNK2 and upregulation of TNF, interleukin (IL)-1beta, IL-6, and IL-10. "...

[All Refs in Pubmed]



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