Basic Informations of Interleukin-6

Entrez Gene ID: 16193 [Pubmed]

UniProt Protein Name: Interleukin-6

UniProt ID: P08505


Related Drug:

No Related Drugs

References

PMID:16820587|Circulation. 2006;114[suppl I]:I-282–I-289
..."Interestingly, TNFR1 ablation improved postischemic myocardial function, decreased activation of p38 mitogen-activated protein kinase, and reduced expression of interleukins-1beta and -6 in males but not in females."...

PMID:17242282|Circulation. 2007;115:501-508
..."Plasma concentrations of proinflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-6, IL-12, and regulated on activation normal T cell expressed and secreted were reduced by FTY720 administration"...

PMID:20100971|Circulation. 2010;121:684-691
..."Previously, we reported that pretreatment of IL-11, an IL-6 family cytokine, activates the glycoprotein 130 signaling pathway in cardiomyocytes and prevents ischemia/reperfusion injury in vivo;"...

PMID:20176988|Circulation. 2010;121:1124-1133
..."CD137 signaling promoted the production of inflammatory molecules, including monocyte chemoattractant protein-1, interleukin-6, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1, in endothelial cells. "...

PMID:20368519|Circulation. 2010;121:1746-1755
..."In addition, the treatment diminished circulating IL-6 and granulocyte colony-stimulating factor levels and limited CXCL1 expression and macrophage content within the aortas"...

PMID:20585009|Circulation. 2010;122:145-155
..."Impaired downregulation of gp130-mediated STAT3 activation in subacute infarction promotes cardiac inflammation, adverse remodeling, and heart failure, suggesting a potential causative role of high interleukin-6 serum levels after myocardial infarction."...

PMID:21747053|Circulation. 2011;124:406-415
...Silencing and overexpression experiments in isolated neonatal rat cardiomyocytes showed that Hsp22 activates STAT3 via production of interleukin-6 by the transcription factor nuclear factor-κB. ...

PMID:18268142|Circulation. 2008;117:1055-1064
..."In addition, ptx3-deficient mice with acute myocardial infarction showed higher circulating levels of interleukin-6 and increased C3 deposition in lesional tissue."...

PMID:18332263|Circulation. 2008;117:1574-1582
..."Myocardial interferon-beta1, interferon-gamma, interleukin-6, interleukin-10, and macrophage inflammatory protein-1alpha expression was elevated in MMP-9 KO mice as measured by quantitative real-time polymerase chain reaction and ELISA."...

PMID:19255345|Circulation. 2009;119:1386-1397
..."Compared with sham, WT HF hearts exhibited significant remodeling with robust activation of nuclear factor (NF)-kappaB, p38 mitogen-activated protein kinase, and JNK2 and upregulation of TNF, interleukin (IL)-1beta, IL-6, and IL-10. "...

PMID:19487598|Circulation. 2009;119:3017-3027
..."HO-1 expression levels correlated with the plaque destabilizing factors matrix metalloproteinase-9, interleukin-8, and interleukin-6. "...

PMID:19506106|Circulation. 2009;119:3125-3132
..." Pretreatment with rosiglitazone inhibited the Ang II-induced expression of angiotensin type 1a Ang II receptor while having no effect on the angiotensin type 2 Ang II receptor, in addition to reducing Ang II-induced expression of E-selectin, tumor necrosis factor-alpha, and interleukin-6."...

[All Refs in Pubmed]



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