Basic Informations of Interleukin 6 signal transducer

Entrez Gene ID: 16195 [Pubmed]

UniProt Protein Name: Interleukin 6 signal transducer

UniProt ID: Q6PDI9

Related Drug:

No Related Drugs


PMID:17101849|Circulation. 2006;114:2364-2373
...SOCS3-mediated regulation of gp130 signaling can affect susceptibility to viral infection in the heart....

PMID:20100971|Circulation. 2010;121:684-691
...Activation of the IL-11/glycoprotein 130/STAT3 axis may be a novel therapeutic strategy against cardiovascular diseases....

PMID:20585009|Circulation. 2010;122:145-155
..."Impaired downregulation of gp130-mediated STAT3 activation in subacute infarction promotes cardiac inflammation, adverse remodeling, and heart failure, suggesting a potential causative role of high interleukin-6 serum levels after myocardial infarction."...

PMID:22082679|Circulation. 2011;124:2690-2701
...Suppressor of cytokine signaling-3 (SOCS3) is a key negative-feedback regulator of the gp130 receptor that provides crucial signaling for cardiac hypertrophy and survival; ...

[All Refs in Pubmed]

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