Basic Informations of Mothers against decapentaplegic homolog 3

Entrez Gene ID: 17127 [Pubmed]

UniProt Protein Name: Mothers against decapentaplegic homolog 3

UniProt ID: Q8BUN5

Related Drug:

No Related Drugs


PMID:17967775|Circulation. 2007;116: 2127-2138
..."Transforming growth factor-beta-mediated induction of procollagen type III and tenascin-C in isolated cardiac fibroblasts was dependent on Smad3, which suggests that decreased fibrotic remodeling in infarcted Smad3-null hearts may be due to abrogation of the profibrotic transforming growth factor-beta responses."...

PMID:20823384|Circulation. 2010;122:1200-1209
..."The numbers of phosphorylated Smad2-, phosphorylated Smad3-, and phosphorylated ERK1/2 MAPK-, but not pAkt/PKB-, positive cells were significantly increased in PAI-1-deficient myocardial tissues. "...

PMID:21282499|Circulation. 2011;123:584-593
...Omega-3 fatty acids prevent cardiac fibrosis and cardiac dysfunction by blocking transforming growth factor-β1-induced phospho-Smad2/3 nuclear translocation through activation of the cyclic GMP/protein kinase G pathway in cardiac fibroblasts....

[All Refs in Pubmed]

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