Basic Informations of 72 kDa type IV collagenase

Entrez Gene ID: 17390 [Pubmed]

UniProt Protein Name: 72 kDa type IV collagenase

UniProt ID: P33434


Related Drug:

DrugBank IDDrug Name
DB01630SC-74020
DB01197Captopril
DB00786Marimastat

References

PMID:17242279|Circulation. 2007;115:475-482
..."Increased inflammation in the absence of Synd1 resulted in increased monocyte chemoattractant protein-1 expression, increased activity of matrix metalloproteinase-2 and -9, and decreased activity of tissue transglutaminase, associated with increased collagen fragmentation and disorganization."...

PMID:20212283|Circulation. 2010;121:1338-1346
..."The severity of aneurysm among these 3 groups positively correlates with C9 deposition, and/or the activities of MMP2 and MMP9, and/or the levels of phosphorylated c-Jun, c-Fos, IKK-alpha/beta, and p65."...

PMID:20823384|Circulation. 2010;122:1200-1209
..."Histological evaluation of myocardial tissues derived from aged PAI-1-deficient mice revealed myocardial fibrosis resulting from excessive accumulation of collagen. Immunohistochemical characterization revealed that the levels of matrix metalloproteinase-2, matrix metalloproteinase-9, and transforming growth factor-β1/2 and the number of Mac3-positive and fibroblast specific protein-1-positive cells were significantly elevated in aged PAI-1-deficient myocardial tissues compared with controls."...

PMID:21041693|Circulation. 2010;122:2039-2047
...MMP-2 localizes to titin at the Z-disk region of the cardiac sarcomere and contributes to titin degradation in myocardial ischemia/reperfusion injury....

PMID:21986287|Circulation. 2011;124:2082-2093
...Matrix metalloproteinase-2-mediated chemokine cleavage has an important role in cardiac inflammation as a negative feedback mechanism....

[All Refs in Pubmed]



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