Basic Informations of Matrix metalloproteinase-9

Entrez Gene ID: 17395 [Pubmed]

UniProt Protein Name: Matrix metalloproteinase-9

UniProt ID: P41245

Related Drug:

DrugBank IDDrug Name
DB036832-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid


PMID:16534014|Circulation. 2006;113:1605-1614
... Estradiol preserves the integrity of ischemic tissue by augmenting the mobilization and incorporation of BM-derived EPCs into sites of neovascularization by eNOS-mediated augmentation of MMP-9 expression in the BM...

PMID:17242279|Circulation. 2007;115:475-482
..."Increased inflammation in the absence of Synd1 resulted in increased monocyte chemoattractant protein-1 expression, increased activity of matrix metalloproteinase-2 and -9, and decreased activity of tissue transglutaminase, associated with increased collagen fragmentation and disorganization."...

PMID:17353445|Circulation. 2007;115:1398-1407
...These mice also showed reduced cardiac matrix metalloproteinase-9 activity and improved cardiac function...

PMID:20212283|Circulation. 2010;121:1338-1346
..."The severity of aneurysm among these 3 groups positively correlates with C9 deposition, and/or the activities of MMP2 and MMP9, and/or the levels of phosphorylated c-Jun, c-Fos, IKK-alpha/beta, and p65."...

PMID:20823384|Circulation. 2010;122:1200-1209
..."Histological evaluation of myocardial tissues derived from aged PAI-1-deficient mice revealed myocardial fibrosis resulting from excessive accumulation of collagen. Immunohistochemical characterization revealed that the levels of matrix metalloproteinase-2, matrix metalloproteinase-9, and transforming growth factor-β1/2 and the number of Mac3-positive and fibroblast specific protein-1-positive cells were significantly elevated in aged PAI-1-deficient myocardial tissues compared with controls."...

PMID:18332263|Circulation. 2008;117:1574-1582
..."Myocardial interferon-beta1, interferon-gamma, interleukin-6, interleukin-10, and macrophage inflammatory protein-1alpha expression was elevated in MMP-9 KO mice as measured by quantitative real-time polymerase chain reaction and ELISA."...

PMID:18606918|Circulation. 2008;118:363-372
... Their activation coincided with the development of myocardial necrosis and fibrosis and correlated with the upregulation of gene expression of matrix metalloproteinase-9....

PMID:19487598|Circulation. 2009;119:3017-3027
..."HO-1 expression levels correlated with the plaque destabilizing factors matrix metalloproteinase-9, interleukin-8, and interleukin-6. "...

[All Refs in Pubmed]

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