Basic Informations of Nuclear factor of activated T-cells c1 isoform IA-VIII

Entrez Gene ID: 18018 [Pubmed]

UniProt Protein Name: Nuclear factor of activated T-cells c1 isoform IA-VIII

UniProt ID: B5B2N5

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PMID:16952979|Circulation. 2006;114:1159-1168
...This study suggests that inhibition of the calcineurin/NFAT signaling cascade by Foxo and release of this repressive action by the PI3K/Akt pathway are important mechanisms whereby Foxo factors govern cell growth in the heart...

PMID:16952980|Circulation. 2006;114:1269-1276
..."Our results provide the first evidence that specific TFs identified in murine models (MEF2, NKX, NFAT, and GATA) are associated with human heart failure. Moreover, these data implicate specific members of the FOX family of TFs (FOXC1, C2, P1, P4, and O1A) not previously suggested in heart failure pathogenesis."...

PMID:19451351|Circulation. 2009;119:2789-2797
..."Cardiac aging in mice is accompanied by accumulation of mitochondrial protein oxidation, increased mitochondrial DNA mutations and deletions and mitochondrial biogenesis, increased ventricular fibrosis, enlarged myocardial fiber size, decreased cardiac SERCA2 protein, and activation of the calcineurin-nuclear factor of activated T-cell pathway. "...

PMID:19752325|Circulation. 2009;120:1231-1240
..."These functional changes were accompanied by sustained molecular effects toward the same direction; by decreasing [Ca(2+)](i) and inhibiting GSK-3beta, DHEA inhibited the nuclear factor of activated T cells transcription factor, thus increasing expression of Kv channels (Kv1.5) and contributing to sustained mitochondrial depolarization."...

[All Refs in Pubmed]

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