Basic Informations of Nuclear factor NF-kappa-B p105 subunit

Entrez Gene ID: 18033 [Pubmed]

UniProt Protein Name: Nuclear factor NF-kappa-B p105 subunit

UniProt ID: P25799


Related Drug:

DrugBank IDDrug Name
DB08814Triflusal
DB01411Pranlukast
DB01041Thalidomide

References

PMID:16820585|Circulation. 2006;114[suppl I]:I-270–I-274
..."A c-Jun NH(2)-terminal kinase (JNK) activation was determined by Western blotting, nuclear factor (NF)-kappaB activity was detected by gel-shift assay, and cytokine expression was measured by ribonuclease protection assay."...

PMID:16818815|Circulation. 2006;114:150-159
..."Here, we report that endogenous integrin-linked kinase (ILK) is a novel molecule that responds to hypoxia in ECs that regulates the expression of stromal cell-derived factor-1 (SDF-1) and intercellular adhesion molecule-1 (ICAM-1) through nuclear factor-kappaB and hypoxia-inducible factor-1alpha and induces recruitment of EPCs to ischemic areas"...

PMID:17389268|Circulation. 2007;115:1885-1894
..."As an inhibitor of nuclear factor-kappaB signaling, A20 protects against apoptosis, inflammation, and cardiac hypertrophy. "...

PMID:17785622|Circulation. 2007;116: 1577-1584
..."In transgenic mice with cardiac-specific expression of a dominant-negative mutant of IkappaB alpha (IkappaB alpha(S32A,S36A)), the upregulation of phosphorylated IkappaB alpha, activation of NF-kappaB, and cardiac COX-2 protein expression 3 days after iNOS gene therapy were abrogated, which was associated with the abolishment of the cardioprotective effects afforded by iNOS gene therapy."...

PMID:20212283|Circulation. 2010;121:1338-1346
..." Furthermore, we demonstrated that the membrane attack complex directly induced gene expression of matrix metalloproteinase-2 and -9 in vitro, which required activation of the activator protein-1 and nuclear factor-kappaB signaling pathways."...

PMID:21242479|Circulation. 2011;123:400-408
..."Mechanistically, cardiomyocytes lacking MR displayed accelerated stress-induced activation and subsequent suppression of nuclear factor-κB and reduced apoptosis early after myocardial infarction."...

PMID:21747053|Circulation. 2011;124:406-415
...Silencing and overexpression experiments in isolated neonatal rat cardiomyocytes showed that Hsp22 activates STAT3 via production of interleukin-6 by the transcription factor nuclear factor-κB. ...

PMID:18574060|Circulation. 2008;117:3216-3226
..."In addition, HMGB1 inhibition with recombinant HMGB1 box A suggested an involvement of the mitogen-activated protein kinases jun N-terminal kinase and extracellular signal-regulated kinase 1/2, as well as the nuclear transcription factor nuclear factor-kappaB in I/R injury."...

PMID:19752329|Circulation. 2009;120:1222-1230
...These results also reveal an important role of nuclear factor-kappaB in both basal and iNOS-induced expression of cardiac HO-1. ...

PMID:19770394|Circulation. 2009;120:1401-1414
..."IRAK-4(-/-) mice also demonstrated attenuated cardiac dilation and decreased inflammation in the infarcted myocardium, which was associated with less proinflammatory and Th1 cytokine expression mediated by suppression of nuclear factor-kappaB and c-Jun N-terminal kinase activation. "...

[All Refs in Pubmed]



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