Basic Informations of NF-kappa-B inhibitor alpha

Entrez Gene ID: 18035 [Pubmed]

UniProt Protein Name: NF-kappa-B inhibitor alpha

UniProt ID: Q9Z1E3

Related Drug:

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PMID:17030682|Circulation. 2006;114:1838-1846
..."Treatment with sorbinil blunted the activation of protein kinase C, c-Jun NH2-terminal kinase, and p38, as well as phosphorylation of interleukin receptor-associated kinase, IkappaB-alpha, IkappaB kinase complex-alpha/beta, and phospholipase-gamma1 and -beta1."...

PMID:17785622|Circulation. 2007;116: 1577-1584
..."In transgenic mice with cardiac-specific expression of a dominant-negative mutant of IkappaB alpha (IkappaB alpha(S32A,S36A)), the upregulation of phosphorylated IkappaB alpha, activation of NF-kappaB, and cardiac COX-2 protein expression 3 days after iNOS gene therapy were abrogated, which was associated with the abolishment of the cardioprotective effects afforded by iNOS gene therapy."...

PMID:19752329|Circulation. 2009;120:1222-1230
..." In transgenic mice with cardiomyocyte-restricted expression of a dominant negative mutant of IkappaBalpha (IkappaBalpha(S32A,S36A)), both basal HO-1 levels and upregulation of HO-1 by iNOS gene transfer were suppressed. "...

[All Refs in Pubmed]

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