Basic Informations of Nitric oxide synthase, inducible

Entrez Gene ID: 18126 [Pubmed]

UniProt Protein Name: Nitric oxide synthase, inducible

UniProt ID: P29477


Related Drug:

DrugBank IDDrug Name
DB08814Triflusal
DB08750"1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE"
DB082144-(1H-IMIDAZOL-1-YL)PHENOL
DB07405"1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE"
DB07389N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE
DB07388ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
DB07318"N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE"
DB07306ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
DB07029"4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE"
DB07011"(3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE"
DB07008"4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE"
DB07007"(3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine"
DB07003"(2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine"
DB070024-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile
DB06916"N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE"
DB06879"5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE"
DB045345-Nitroindazole
DB04400"7,8-Dihydrobiopterin"
DB03953L-Thiocitrulline
DB03449N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine
DB03271"7,8-Dihydro-L-Biopterin"
DB03144N-Omega-Hydroxy-L-Arginine
DB031006-Nitroindazole
DB03014Heme
DB02692"(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin"
DB02644N-Omega-Propyl-L-Arginine
DB02539S-Ethylisothiourea
DB02533Aminoguanidine
DB02462Thiocoumarin
DB02234Ethylisothiourea
DB022077-Nitroindazole
DB02044N-(3-(Aminomethyl)Benzyl)Acetamidine
DB019973-Bromo-7-Nitroindazole
DB018354r-Fluoro-N6-Ethanimidoyl-L-Lysine
DB01686"N,N-dimethylarginine"
DB01234Dexamethasone
DB01110Miconazole
DB00155L-Citrulline
DB00125L-Arginine

References

PMID:16505177|Circulation. 2006;113:1226-1234
..." In rats and mice, activation of the RAGE axis was associated with increases in inducible nitric oxide synthase expression and levels of nitric oxide, cyclic guanosine monophosphate (cGMP), and nitrotyrosine."...

PMID:17030682|Circulation. 2006;114:1838-1846
..."These changes were associated with decreased myocardial nuclear factor-kappaB and activating protein-1 activity, prostaglandin E2 production, induction of cyclooxygenase 2, and inducible nitric oxide synthase"...

PMID:17339545|Circulation. 2007;115:1408-1416
...The present study demonstrates that adiponectin is a natural molecule that protects hearts from ischemia/reperfusion injury by inhibition of iNOS and nicotinamide adenine dinucleotide phosphate-oxidase protein expression and resultant oxidative/nitrative stress...

PMID:17785622|Circulation. 2007;116: 1577-1584
..."In transgenic mice with cardiac-specific expression of a dominant-negative mutant of IkappaB alpha (IkappaB alpha(S32A,S36A)), the upregulation of phosphorylated IkappaB alpha, activation of NF-kappaB, and cardiac COX-2 protein expression 3 days after iNOS gene therapy were abrogated, which was associated with the abolishment of the cardioprotective effects afforded by iNOS gene therapy."...

PMID:18413498|Circulation. 2008;117:2211-2223
..."Importantly, activation of the renin-angiotensin system was noted in the triply n/i/eNOS(-/-) mice, and long-term oral treatment with an angiotensin II type 1 receptor blocker significantly suppressed coronary arteriosclerotic lesion formation and the occurrence of spontaneous myocardial infarction and improved the prognosis of those mice, along with ameliorating the metabolic abnormalities."...

PMID:18936326|Circulation. 2008;118:1970-1978
...Cardiomyocyte-restricted expression of iNOS provides sustained cardioprotection....

PMID:19752329|Circulation. 2009;120:1222-1230
...These results also reveal an important role of nuclear factor-kappaB in both basal and iNOS-induced expression of cardiac HO-1. ...

[All Refs in Pubmed]



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