Basic Informations of Nitric oxide synthase, endothelial

Entrez Gene ID: 18127 [Pubmed]

UniProt Protein Name: Nitric oxide synthase, endothelial

UniProt ID: P70313


Related Drug:

DrugBank IDDrug Name
DB08019"N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine"
DB08018"N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE"
DB07388ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
DB07244"5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE"
DB07001"(3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine"
DB04559N-(Chlorophenyl)-N'-Hydroxyguanidine
DB045345-Nitroindazole
DB04223Nitroarginine
DB04018S-Isopropyl-Isothiourea
DB03974L-Homoarginine
DB03963S-(Dimethylarsenic)Cysteine
DB03918"6s-5,6,7,8-Tetrahydrobiopterin"
DB03910"S,S'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea"
DB03707S-Ethyl-N-Phenyl-Isothiourea
DB03332"5,6-Cyclic-Tetrahydropteridine"
DB03305N5-Iminoethyl-L-Ornithine
DB03144N-Omega-Hydroxy-L-Arginine
DB031006-Nitroindazole
DB030657-Nitroindazole-2-Carboxamidine
DB03014Heme
DB02994Hydroxydimethylarsine Oxide
DB02979"N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane"
DB02911"2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine"
DB02692"(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin"
DB02589Se-Ethyl-Isoselenourea
DB023352-Aminothiazoline
DB02234Ethylisothiourea
DB022077-Nitroindazole
DB02141"S,S'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea"
DB02077L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide
DB02048"1,2,4-Triazole-Carboxamidine"
DB02044N-(3-(Aminomethyl)Benzyl)Acetamidine
DB02027N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine
DB019973-Bromo-7-Nitroindazole
DB01833L-2-Amino-4-(Guanidinooxy)Butyric Acid
DB01821"L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide"
DB01686"N,N-dimethylarginine"
DB01110Miconazole
DB00360Tetrahydrobiopterin
DB00155L-Citrulline
DB00125L-Arginine

References

PMID:16391154|Circulation. 2006;113:286-295
...This effect is partially dependent on endogenous nitric oxide generated by NOS3...

PMID:16534014|Circulation. 2006;113:1605-1614
... Estradiol preserves the integrity of ischemic tissue by augmenting the mobilization and incorporation of BM-derived EPCs into sites of neovascularization by eNOS-mediated augmentation of MMP-9 expression in the BM...

PMID:17101854|Circulation. 2006;114:2498-2507
...PTP1B inhibition stimulated early eNOS phosphorylation and increased phosphorylation of Akt....

PMID:17116771|Circulation. 2006;114:2655-2662
..." Mice given atorvastatin through gastric gavage showed increased AMPK, acetyl-CoA carboxylase, and endothelial NO synthase phosphorylation in mouse aorta and myocardium."...

PMID:17638931|Circulation. 2007;116:506-514
...These findings implicate NOS3 as a key mediator in the development of left ventricular dysfunction after administration of doxorubicin...

PMID:17606840|Circulation. 2007;116:535-544
..."However, eNOS is obligatorily required for the development of the cardioprotective effects of late PC and acts as the trigger of this process by activating the PKC epsilon-MEK-1/2-p44/42 mitogen-activated protein kinase pathway, leading to Ser-727 phosphorylation of STAT1 and STAT3 and consequent upregulation of STAT-dependent genes such as cyclooxygenase-2"...

PMID:20083679|Circulation. 2010;121:537-548
..."CO enhanced EC proliferation via rapid activation of RhoA (Ras homolog gene family, member A), followed by downstream phosphorylation of Akt, endothelial nitric oxide (NO) synthase phosphorylation, and a 60% increase in NO generation by ECs. "...

PMID:20176991|Circulation. 2010;121:1104-1112
..."Cholesterol enhanced the messenger RNA expression (quantitative, real-time reverse-transcription polymerase chain reaction) of vascular endothelial growth factor and inhibited Notch1 messenger RNA expression in both ApoE(-/-) and WT EPCs, whereas endothelial nitric oxide synthase messenger RNA expression increased in ApoE(-/-) EPCs and declined in WT EPCs after cholesterol exposure. "...

PMID:20837912|Circulation. 2010;122:S185-S192
..." Adropin markedly upregulated vascular endothelial growth factor receptor-2 (VEGFR2) transcript and protein levels, and in VEGFR2-silenced endothelial cells, adropin failed to induce phosphorylation of endothelial NO synthase, Akt, and extracellular signal regulated kinase 1/2, supporting VEGFR2 as an upstream target of adropin-mediated endothelial NO synthase activation. "...

PMID:21282499|Circulation. 2011;123:584-593
...Eicosapentaenoic acid and docosahexaenoic acid increased phosphorylated endothelial nitric oxide synthase and endothelial nitric oxide synthase protein levels and nitric oxide production....

PMID:21788590|Circulation. 2011;124:731-740
..."Collectively, we demonstrate that augmented endothelial Nox4 expression promotes angiogenesis and recovery from hypoxia in an eNOS-dependent manner."...

PMID:22082678|Circulation. 2011;124:2735-2745
..."ADMA profoundly impairs nitric oxide synthesis of PMNs, resulting in increased PMN adhesion to endothelial cells, superoxide generation, and release of MPO."...

PMID:18268143|Circulation. 2008;117:1045-1054
..."These results demonstrate that endothelium-specific GTPCH I overexpression abrogates O2(-) production and preserves eNOS phosphorylation, which results in preserved structural and functional integrity of resistance mesenteric arteries and lowered blood pressure in low-renin hypertension."...

PMID:18413498|Circulation. 2008;117:2211-2223
..."Importantly, activation of the renin-angiotensin system was noted in the triply n/i/eNOS(-/-) mice, and long-term oral treatment with an angiotensin II type 1 receptor blocker significantly suppressed coronary arteriosclerotic lesion formation and the occurrence of spontaneous myocardial infarction and improved the prognosis of those mice, along with ameliorating the metabolic abnormalities."...

PMID:18474817|Circulation. 2008;117:2626-2636
..."Oral BH4 was then administered for 5 more weeks of pressure overload. Without reducing loading, BH4 reversed hypertrophy and fibrosis, recoupled endothelial NOS, lowered oxidant stress, and improved chamber and myocyte function, whereas untreated hearts worsened. "...

PMID:18663085|Circulation. 2008;118:731-742
..."This adverse effect of apoCIII was mediated by its activation of PKCbeta, which inhibits the IRS-1/PI3K/Akt/eNOS pathway."...

PMID:18824773|Circulation. 2008;118[suppl 1]:S71–S77
..."Endothelium-targeted overexpression of GTP cyclohydrolase 1 (GCH), the rate limiting enzyme in BH4 synthesis, increased levels of tetrahydrobiopterin (BH4), reduced endothelial superoxide, improved eNOS coupling, and reduced vein graft atherosclerosis in transgenic GCH/ApoE-KO mice compared to ApoE-KO controls. "...

PMID:18955669|Circulation. 2008;118:2073-2080
..." In parallel, endothelial NO synthase expression was upregulated only in JNK2(-/-) HCD animals, whereas the expression of antioxidant defense systems such as extracellular superoxide dismutase and manganese superoxide dismutase was decreased in WT but not in JNK2(-/-) HCD mice."...

PMID:19546390|Circulation. 2009;120:50-59
..." As a consequence, 2 key hypoxia-inducible proangiogenic actors, vascular endothelial growth factor-A and endothelial nitric oxide synthase, were upregulated at the mRNA and protein levels. "...

[All Refs in Pubmed]



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