Basic Informations of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Entrez Gene ID: 18706 [Pubmed]

UniProt Protein Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

UniProt ID: P42337


Related Drug:

No Related Drugs

References

PMID:16952979|Circulation. 2006;114:1159-1168
...This study suggests that inhibition of the calcineurin/NFAT signaling cascade by Foxo and release of this repressive action by the PI3K/Akt pathway are important mechanisms whereby Foxo factors govern cell growth in the heart...

PMID:17101854|Circulation. 2006;114:2498-2507
...This restoration was reduced by inhibitors of eNOS and phosphatidylinositol-3 kinase...

PMID:20837912|Circulation. 2010;122:S185-S192
...We report a potential endothelial protective role of adropin that is likely mediated via upregulation of endothelial NO synthase expression through the VEGFR2-phosphatidylinositol 3-kinase-Akt and VEGFR2-extracellular signal regulated kinase 1/2 pathways....

PMID:18663085|Circulation. 2008;118:731-742
..."This adverse effect of apoCIII was mediated by its activation of PKCbeta, which inhibits the IRS-1/PI3K/Akt/eNOS pathway."...

PMID:18711014|Circulation. 2008;118:1021-1033
..."PPAR-delta activation in EPCs phosphorylated Akt, and this phosphorylation was mediated not only by genomic but also by nongenomic pathways through interaction with the regulatory subunit of phosphatidylinositol 3-kinase. "...

[All Refs in Pubmed]



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