Basic Informations of Protein kinase C alpha type

Entrez Gene ID: 18750 [Pubmed]

UniProt Protein Name: Protein kinase C alpha type

UniProt ID: P20444

Related Drug:

DrugBank IDDrug Name
DB00163Vitamin E


PMID:16380548|Circulation. 2006;113:60-66
...DGKzeta regulated PKC activity by controlling cellular diacylglycerol levels....

PMID:16880328|Circulation. 2006;114:574-582
..."Mechanistically, PKCalpha directly regulates Ca2+ handling by altering the phosphorylation status of inhibitor-1, which in turn suppresses protein phosphatase-1 activity, thus modulating phospholamban activity and secondarily, the sarcoplasmic reticulum Ca2+ ATPase."...

PMID:17030682|Circulation. 2006;114:1838-1846
..."Treatment with sorbinil blunted the activation of protein kinase C, c-Jun NH2-terminal kinase, and p38, as well as phosphorylation of interleukin receptor-associated kinase, IkappaB-alpha, IkappaB kinase complex-alpha/beta, and phospholipase-gamma1 and -beta1."...

PMID:20679547|Circulation. 2010;122:717-728
..."rhACE2 treatment inhibited Ang II-mediated activation of protein kinase C-alpha and protein kinase C-beta1 protein levels and phosphorylation of the extracellular signal-regulated 1/2, Janus kinase 2, and signal transducer and activator of transcription 3 signaling pathways in wild-type mice."...

PMID:18427129|Circulation. 2008;117:2241-2252
..."In adult density-gradient separated BMMNCs, canonical Wnt3a promotes stemness, proliferation, and hematopoietic commitment, whereas noncanonical signaling via Wnt11 induces robust cardiomyogenic differentiation in a protein kinase C- and c-Jun-N-terminal kinase-dependent manner."...

[All Refs in Pubmed]

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