Basic Informations of Plasminogen activator inhibitor 1

Entrez Gene ID: 18787 [Pubmed]

UniProt Protein Name: Plasminogen activator inhibitor 1

UniProt ID: G5E899


Related Drug:

DrugBank IDDrug Name
DB00197Troglitazone
DB00055Drotrecogin alfa
DB00031Tenecteplase
DB00029Anistreplase
DB00015Reteplase
DB00013Urokinase
DB00009Alteplase

References

PMID:20733098|Circulation. 2010;122:1026-1036
..."As assessed by immunohistochemistry, reverse transcription polymerase chain reaction, and flow cytometry, C5aR was expressed in lesional and cultured vascular smooth muscle cells, upregulated by injury or tumor necrosis factor-alpha, and reduced by C5aRA. Plasma levels and neointimal plasminogen activator inhibitor-1 peaked 1 week after injury and were downregulated in C5aRA-treated mice. "...

PMID:20823384|Circulation. 2010;122:1200-1209
..."Histological evaluation of myocardial tissues derived from aged PAI-1-deficient mice revealed myocardial fibrosis resulting from excessive accumulation of collagen. Immunohistochemical characterization revealed that the levels of matrix metalloproteinase-2, matrix metalloproteinase-9, and transforming growth factor-β1/2 and the number of Mac3-positive and fibroblast specific protein-1-positive cells were significantly elevated in aged PAI-1-deficient myocardial tissues compared with controls."...

PMID:18427128|Circulation. 2008;117:2253-2261
..." Expression of tumor necrosis factor-alpha, monocyte chemoattractant protein-1, plasminogen activator inhibitor type 1, and macrophage protein CD68 increased, and expression of adiponectin and peroxisome proliferator-activated receptor-gamma decreased in retroperitoneal adipose tissue from obese versus lean mice."...

[All Refs in Pubmed]



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