Basic Informations of Urokinase-type plasminogen activator

Entrez Gene ID: 18792 [Pubmed]

UniProt Protein Name: Urokinase-type plasminogen activator

UniProt ID: P06869


Related Drug:

DrugBank IDDrug Name
DB08697"4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide"
DB08072"4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE"
DB07626"4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide"
DB07625"4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide"
DB07129"(2R)-1-(2,6-dimethylphenoxy)propan-2-amine"
DB071221-[4-(2-oxo-2-phenylethyl)phenyl]guanidine
DB070766-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE
DB06857N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE
DB068566-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE
DB068556-FLUORO-2-(2-HYDROXY-3-ISOBUTOXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE
DB068542-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE
DB04172"[2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-Alanine"
DB040598-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide
DB03876"Thieno[2,3-B]Pyridine-2-Carboxamidine"
DB038656-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
DB03782N-(1-Adamantyl)-N'-(4-Guanidinobenzyl)Urea
DB037292-Amino-5-Hydroxy-Benzimidazole
DB03476Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine
DB03159CRA_8696
DB031364-Iodobenzo[B]Thiophene-2-Carboxamidine
DB03127Benzamidine
DB030826-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide
DB030467-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide
DB02705"6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine"
DB02551"6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine"
DB02526CRA_10655
DB02473"6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine"
DB023986-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine
DB021932-(2-Hydroxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine
DB019776-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine
DB019052-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine
DB00594Amiloride
DB00013Urokinase

References

PMID:16880329|Circulation. 2006;114:565-573
..." Loss of uPA or MMP activity reduces the cardiac inflammatory response after CVB3 infection, thereby protecting against cardiac injury, dilatation, and failure during CVB3-induced myocarditis."...

PMID:21969013|Circulation. 2011;124:1848-1859
..."Our data suggest that endothelial uPA promotes intravascular adherence, whereas leukocyte uPA facilitates the subsequent paracellular transmigration of neutrophils during I/R. "...

[All Refs in Pubmed]



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