Basic Informations of Cardiac phospholamban

Entrez Gene ID: 18821 [Pubmed]

UniProt Protein Name: Cardiac phospholamban

UniProt ID: P61014

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PMID:16880328|Circulation. 2006;114:574-582
..."Mechanistically, PKCalpha directly regulates Ca2+ handling by altering the phosphorylation status of inhibitor-1, which in turn suppresses protein phosphatase-1 activity, thus modulating phospholamban activity and secondarily, the sarcoplasmic reticulum Ca2+ ATPase."...

PMID:17646583|Circulation. 2007;116:596-605
..."Treatment of transgenic animals with the Gi/o inhibitor pertussis toxin normalized the phospholamban phosphorylation by protein kinase A, reversed the action potential prolongation, and significantly reduced the frequency of cardiac arrhythmias in Ras transgenic animals."...

PMID:18071070|Circulation. 2008;117:61-69
..." In addition, phospholamban phosphorylation was reduced (P=0.015), sarcoplasmic reticulum Ca2+-ATPase activity was impaired (P<0.0001), and cardiac myocytes showed marked abnormalities in calcium transient formation (P=0.001)."...

PMID:18541744|Circulation. 2008;117:3187-3198
..."These effects could be explained, at least in part, through modulation of phospholamban phosphorylation status."...

PMID:19139388|Circulation. 2009;119:436-444
..."The data demonstrate an association between the dose-dependent inhibition of SERCA2a activity by PLN(wt) and the time of onset of heart failure and show that a weak inhibitor of SERCA2a, PLN(R9C), which is diminished in its ability to modify the level of SERCA2a activity, leads to heart failure despite fast sarcoplasmic reticulum Ca(2+) reuptake."...

[All Refs in Pubmed]

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