Basic Informations of Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Entrez Gene ID: 19055 [Pubmed]

UniProt Protein Name: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

UniProt ID: P63328


Related Drug:

No Related Drugs

References

PMID:16847152|Circulation. 2006;114:298-308
..."Surprisingly, end-diastolic and end-systolic ventricular dimensions and contractility were normalized in the presence of severely hypertrophied left ventricular walls on MEF2 inhibition in calcineurin transgenic mice"...

PMID:16952979|Circulation. 2006;114:1159-1168
...This study suggests that inhibition of the calcineurin/NFAT signaling cascade by Foxo and release of this repressive action by the PI3K/Akt pathway are important mechanisms whereby Foxo factors govern cell growth in the heart...

PMID:19451351|Circulation. 2009;119:2789-2797
..."Cardiac aging in mice is accompanied by accumulation of mitochondrial protein oxidation, increased mitochondrial DNA mutations and deletions and mitochondrial biogenesis, increased ventricular fibrosis, enlarged myocardial fiber size, decreased cardiac SERCA2 protein, and activation of the calcineurin-nuclear factor of activated T-cell pathway. "...

[All Refs in Pubmed]



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