Basic Informations of Prostaglandin G/H synthase 2

Entrez Gene ID: 19225 [Pubmed]

UniProt Protein Name: Prostaglandin G/H synthase 2

UniProt ID: Q05769


Related Drug:

DrugBank IDDrug Name
DB06802Nepafenac
DB06725Lornoxicam
DB04743Nimesulide
DB04552Niflumic Acid
DB03866Prostaglandin G2
DB034771-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole
DB03014Heme
DB02709Resveratrol
DB02266Flufenamic Acid
DB01628Etoricoxib
DB01600Tiaprofenic acid
DB01435Antipyrine
DB01419Antrafenine
DB01404Ginseng
DB01401Trisalicylate-choline
DB01399Salsalate
DB01398Salicylate-sodium
DB01397Magnesium salicylate
DB01294Bismuth Subsalicylate
DB01283Lumiracoxib
DB01050Ibuprofen
DB01041Thalidomide
DB01014Balsalazide
DB01009Ketoprofen
DB00991Oxaprozin
DB00963Bromfenac
DB00945Acetylsalicylic acid
DB00939Meclofenamic acid
DB00936Salicyclic acid
DB00870Suprofen
DB00861Diflunisal
DB00821Carprofen
DB00814Meloxicam
DB00812Phenylbutazone
DB00795Sulfasalazine
DB00788Naproxen
DB00784Mefenamic acid
DB00749Etodolac
DB00712Flurbiprofen
DB00605Sulindac
DB00586Diclofenac
DB00580Valdecoxib
DB00573Fenoprofen
DB00554Piroxicam
DB00533Rofecoxib
DB00500Tolmetin
DB00482Celecoxib
DB00480Lenalidomide
DB00469Tenoxicam
DB00465Ketorolac
DB00461Nabumetone
DB00328Indomethacin
DB00316Acetaminophen
DB00244Mesalazine
DB00233Aminosalicylic Acid
DB00159Icosapent
DB00154gamma-Homolinolenic acid

References

PMID:17030682|Circulation. 2006;114:1838-1846
..."These changes were associated with decreased myocardial nuclear factor-kappaB and activating protein-1 activity, prostaglandin E2 production, induction of cyclooxygenase 2, and inducible nitric oxide synthase"...

PMID:17606840|Circulation. 2007;116:535-544
..."However, eNOS is obligatorily required for the development of the cardioprotective effects of late PC and acts as the trigger of this process by activating the PKC epsilon-MEK-1/2-p44/42 mitogen-activated protein kinase pathway, leading to Ser-727 phosphorylation of STAT1 and STAT3 and consequent upregulation of STAT-dependent genes such as cyclooxygenase-2"...

PMID:17785622|Circulation. 2007;116: 1577-1584
..."In transgenic mice with cardiac-specific expression of a dominant-negative mutant of IkappaB alpha (IkappaB alpha(S32A,S36A)), the upregulation of phosphorylated IkappaB alpha, activation of NF-kappaB, and cardiac COX-2 protein expression 3 days after iNOS gene therapy were abrogated, which was associated with the abolishment of the cardioprotective effects afforded by iNOS gene therapy."...

PMID:20530000|Circulation. 2010;121:2654-2660
..."Macrophage-COX-2, primarily a source of thromboxane A(2) and prostaglandin (PG)E(2), promotes atherogenesis and exerts a restraint on enzyme expression by lesional cells suggestive of vascular smooth muscle cells, a prominent source of atheroprotective prostacyclin."...

PMID:18347209|Circulation. 2008;117:1701-1710
...Ptges(-/-) mice express cyclooxygenase-2 in inflammatory cells adjacent to the infarct and do not express mPGES-1 in any cells in the heart. ...

PMID:18391113|Circulation. 2008;117:2114-2122
...Our findings reveal that hypoxia-induced pulmonary hypertension and vascular remodeling are exacerbated in the absence of COX-2 with enhanced ET(A) receptor expression and increased PASMC hypertrophy....

[All Refs in Pubmed]



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