Basic Informations of C-C motif chemokine 2

Entrez Gene ID: 20296 [Pubmed]

UniProt Protein Name: C-C motif chemokine 2

UniProt ID: P10148

Related Drug:

No Related Drugs


PMID:16880330|Circulation. 2006;114:583-590
..." We found that CXCL16-/-/LDLR-/- mice have accelerated atherosclerosis, enhanced macrophage recruitment to the aortic arch, and more abundant mRNA for monocyte chemotactic protein-1 and tumor necrosis factor-alpha."...

PMID:17242279|Circulation. 2007;115:475-482
..."Increased inflammation in the absence of Synd1 resulted in increased monocyte chemoattractant protein-1 expression, increased activity of matrix metalloproteinase-2 and -9, and decreased activity of tissue transglutaminase, associated with increased collagen fragmentation and disorganization."...

PMID:17283277|Circulation. 2007;115:584-592
...Defective MCP-1 signaling inhibits the development of ischemic fibrotic cardiomyopathy in mice. ...

PMID:17438151|Circulation. 2007;115:2442-2450
..."PARP inhibition promoted an increase in collagen content, potentially through an increase in tissue inhibitor of metalloproteinase-2, and transmigration of smooth muscle cells to intima of atherosclerotic plaques as well as a decrease in monocyte chemotactic protein-1 production, all of which are markers of plaque stability. "...

PMID:20176988|Circulation. 2010;121:1124-1133
..."CD137 signaling promoted the production of inflammatory molecules, including monocyte chemoattractant protein-1, interleukin-6, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1, in endothelial cells. "...

PMID:20421523|Circulation. 2010;121:2023-2032
..."The tumor necrosis factor-alpha-induced proinflammatory response of SMCs is inhibited by Nurr1, as reflected by reduced interleukin-1beta, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1 expression."...

PMID:18165355|Circulation. 2008;117:1642-1648
..." Genetic deletions of monocyte chemoattractant protein-1 (MCP-1, CCL2), fractalkine (CX3CL1), or their cognate receptors, CCR2 and CX3CR1, markedly reduce atherosclerotic lesion size in murine models of atherosclerosis. "...

PMID:18347211|Circulation. 2008;117:1649-1657
..."CCL2, CX3CR1, and CCR5 play independent and additive roles in atherogenesis. Signals mediated through these pathways critically determine the frequency of circulating monocyte subsets and thereby account for almost all macrophage accumulation into atherosclerotic arteries."...

PMID:18427128|Circulation. 2008;117:2253-2261
..." Expression of tumor necrosis factor-alpha, monocyte chemoattractant protein-1, plasminogen activator inhibitor type 1, and macrophage protein CD68 increased, and expression of adiponectin and peroxisome proliferator-activated receptor-gamma decreased in retroperitoneal adipose tissue from obese versus lean mice."...

PMID:18559699|Circulation. 2008;118:75-83
..."In contrast, atherosclerotic progression was almost completely inhibited by hepatic LOX-1 expression. In addition, plasma monocyte chemotactic protein-1 and lipid peroxide levels were decreased, whereas adiponectin was increased, suggesting decreased systemic oxidative stress. "...

PMID:18824773|Circulation. 2008;118[suppl 1]:S71–S77
..." When we investigated the potential mediators of this reduction, we discovered that mRNA and protein levels of MCP-1 (CCL2) but not RANTES (CCL5) were significantly reduced in GCH/ApoE-KO aortic tissue."...

PMID:19546390|Circulation. 2009;120:50-59
..."In addition, monocyte chemotactic protein-1 mRNA levels and infiltration of Mac-3-positive macrophages were enhanced in ischemic leg of mice treated with shPHD2 and shPHD3. "...

[All Refs in Pubmed]

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