Basic Informations of Stromal cell-derived factor 1

Entrez Gene ID: 20315 [Pubmed]

UniProt Protein Name: Stromal cell-derived factor 1

UniProt ID: H7BX38

Related Drug:

No Related Drugs


PMID:16818815|Circulation. 2006;114:150-159
..."Here, we report that endogenous integrin-linked kinase (ILK) is a novel molecule that responds to hypoxia in ECs that regulates the expression of stromal cell-derived factor-1 (SDF-1) and intercellular adhesion molecule-1 (ICAM-1) through nuclear factor-kappaB and hypoxia-inducible factor-1alpha and induces recruitment of EPCs to ischemic areas"...

PMID:17646584|Circulation. 2007;116:654-663
..."In isolated myocytes, CXCR4 activation by SDF-1alpha resulted in increased phosphorylation of both ERK 1/2 and AKT and decreased phosphorylation of JNK and p38"...

PMID:18040029|Circulation. 2007;116:2818-2829
..."This resulted in a diminished hypoxia response, including decreased stromal cell-derived factor 1 (P<0.005) and vascular endothelial growth factor (P<0.0004). "...

PMID:20048211|Circulation. 2010; 121: 315-324
..."EOC adhesion to fibronectin, fibrinogen, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 under flow conditions, as well as their transmigration toward stromal cell-derived factor-1alpha, was dose-dependently reduced after preincubation with recombinant human sCD40L for 24 hours."...

PMID:18086932|Circulation. 2008;117:206-215
..."Moreover, platelet-derived SDF-1 binding to CXCR4 receptor promotes platelet-induced differentiation of CD34+ cells into endothelial progenitor cells, as verified by colony-forming assays in vitro."...

PMID:18427137|Circulation. 2008;117:2224-2231
..."Here we show that the secreted signaling protein stromal cell-derived factor-1alpha (SDF-1alpha), which activates the cell-survival factor protein kinase B (PKB/Akt) via the G protein-coupled receptor CXCR4, protected tissue after an acute ischemic event in mice and activated Akt within endothelial cells and myocytes of the heart. "...

[All Refs in Pubmed]

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