Basic Informations of E-selectin

Entrez Gene ID: 20339 [Pubmed]

UniProt Protein Name: E-selectin

UniProt ID: Q00690

Related Drug:

No Related Drugs


PMID:17967778|Circulation. 2007;116:2173-2181
..."apoCI expression increased the LPS-induced atherosclerotic lesion area by 60% (P<0.05), concomitant with an increase in LPS-induced plasma levels of fibrinogen and E-selectin."...

PMID:18519846|Circulation. 2008;117:3227-3237
..."To test this hypothesis, we examined the expression and function of PSGL-1 on Ly-6C(hi) and Ly-6C(lo) monocytes from wild-type mice, ApoE(-/-) mice, and mice lacking both ApoE and PSGL-1 genes (ApoE(-/-)/PSGL-1(-/-)). We found that Ly-6C(hi) monocytes expressed a higher level of PSGL-1 and had enhanced binding to fluid-phase P- and E-selectin compared with Ly-6C(lo) monocytes. "...

PMID:19433759|Circulation. 2009;119:2708-2717
..."Deficiency of CD11c decreased firm arrest of mouse monocytes on vascular cell adhesion molecule-1 and E-selectin in a shear flow assay, reduced monocyte/macrophage accumulation in atherosclerotic lesions, and decreased atherosclerosis development in apoE-/- mice on a high-fat diet."...

PMID:19506106|Circulation. 2009;119:3125-3132
..." Pretreatment with rosiglitazone inhibited the Ang II-induced expression of angiotensin type 1a Ang II receptor while having no effect on the angiotensin type 2 Ang II receptor, in addition to reducing Ang II-induced expression of E-selectin, tumor necrosis factor-alpha, and interleukin-6."...

[All Refs in Pubmed]

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