Basic Informations of P-selectin

Entrez Gene ID: 20344 [Pubmed]

UniProt Protein Name: P-selectin

UniProt ID: Q01102


Related Drug:

DrugBank IDDrug Name
DB08813Nadroparin
DB06779Dalteparin
DB03721O-Sialic Acid
DB01109Heparin

References

PMID:17679613|Circulation. 2007;116:764-773
..."Fractalkine expressed by inflamed endothelial cells triggers P-selectin exposure on adherent platelets, which thereby initiates the local accumulation of leukocytes under arterial shear, an essential step in the development of atherosclerotic lesions."...

PMID:21576651|Circulation. 2011;123:2404-2413
..."Similarly, the in vitro adhesion of isolated mouse monocytes to tumor necrosis factor α--stimulated murine endothelial cell monolayers and their migration across the cell layers were strongly reduced in P2Y(1)-deficient compared with wild-type endothelial cells, as was the expression of the adhesion molecules P-selectin, Vascular cell adhesion molecule 1, and intercellular adhesion molecule 1."...

PMID:18519846|Circulation. 2008;117:3227-3237
..."To test this hypothesis, we examined the expression and function of PSGL-1 on Ly-6C(hi) and Ly-6C(lo) monocytes from wild-type mice, ApoE(-/-) mice, and mice lacking both ApoE and PSGL-1 genes (ApoE(-/-)/PSGL-1(-/-)). We found that Ly-6C(hi) monocytes expressed a higher level of PSGL-1 and had enhanced binding to fluid-phase P- and E-selectin compared with Ly-6C(lo) monocytes. "...

[All Refs in Pubmed]



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