Basic Informations of Signal transducer and activator of transcription 3

Entrez Gene ID: 20848 [Pubmed]

UniProt Protein Name: Signal transducer and activator of transcription 3

UniProt ID: P42227


Related Drug:

No Related Drugs

References

PMID:17101849|Circulation. 2006;114:2364-2373
...Increased cardiac cell survival through gp130-signal transducers and activators of transcription-3 signaling appears to play an important role in preserving nondividing cardiac myocytes until specific immune responses begin to clear the virus....

PMID:17606840|Circulation. 2007;116:535-544
..."However, eNOS is obligatorily required for the development of the cardioprotective effects of late PC and acts as the trigger of this process by activating the PKC epsilon-MEK-1/2-p44/42 mitogen-activated protein kinase pathway, leading to Ser-727 phosphorylation of STAT1 and STAT3 and consequent upregulation of STAT-dependent genes such as cyclooxygenase-2"...

PMID:20100971|Circulation. 2010;121:684-691
...IL-11 attenuated cardiac fibrosis after MI through STAT3. ...

PMID:20585009|Circulation. 2010;122:145-155
..."Impaired downregulation of gp130-mediated STAT3 activation in subacute infarction promotes cardiac inflammation, adverse remodeling, and heart failure, suggesting a potential causative role of high interleukin-6 serum levels after myocardial infarction."...

PMID:20679547|Circulation. 2010;122:717-728
..."rhACE2 treatment inhibited Ang II-mediated activation of protein kinase C-alpha and protein kinase C-beta1 protein levels and phosphorylation of the extracellular signal-regulated 1/2, Janus kinase 2, and signal transducer and activator of transcription 3 signaling pathways in wild-type mice."...

PMID:21747053|Circulation. 2011;124:406-415
...Silencing and overexpression experiments in isolated neonatal rat cardiomyocytes showed that Hsp22 activates STAT3 via production of interleukin-6 by the transcription factor nuclear factor-κB. ...

PMID:22082679|Circulation. 2011;124:2690-2701
..."These mice showed increased activation of gp130 downstream signaling targets (STAT3, ERK1/2, AKT, and p38) from 15 weeks of age and developed cardiac dysfunction from approximately 25 weeks of age with signs of heart failure."...

PMID:18824767|Circulation. 2008;118[suppl 1]:S38–S45
..."The deleterious effects of TNFR2 ablation were associated with a decrease in mRNA and protein levels of SOCS3, STAT3, and vascular endothelial growth factor as well as an increase in myocardial interleukin-1-beta production in female hearts. "...

[All Refs in Pubmed]



Network Situation

Node Details

The Selected Node Entrez Gene ID: ;
Protein Name:;

Expand Network with Neighbor Nodes

Click on Compounds Name to View Detail Descriptions
Num.Node NameNode Type
Relationships || Format: ||Change Views || Powered by Cytoscape Web

  • Tips
  • Click on Nodes to expand network with drugs and targets
  • See only TM or pp CVD network by reset with corresponding options
  • Highlight neighbor nodes just mouseover interested nodes
  • Find details of nodes and edges from tips when mouseover
  • Drag nodes or Zoom the network with panel in the bottom-right
  • Nodes and Edges
  • NodesType
    Blue RectTargets
    Yellow RectExpand Targets
    White borderTargets have drug
    Red VeeDrugs
    EdgesType
    Blue Text mining
    Red PPI