Basic Informations of Transforming growth factor beta-1

Entrez Gene ID: 21803 [Pubmed]

UniProt Protein Name: Transforming growth factor beta-1

UniProt ID: P04202


Related Drug:

No Related Drugs

References

PMID:17060383|Circulation. 2006;114:1968-1976
..."Tolerance to oxLDL induced a significant increase in CD4+ CD25+ Foxp3+ cells in spleen and mesenteric lymph nodes, and these cells specifically responded to oxLDL with increased transforming growth factor-beta production"...

PMID:17088457|Circulation. 2006;114:2288-2297
..."Endoglin, an accessory receptor for transforming growth factor-beta in vascular endothelial cells, is essential for angiogenesis during mouse development"...

PMID:17967775|Circulation. 2007;116: 2127-2138
..."Transforming growth factor-beta-mediated induction of procollagen type III and tenascin-C in isolated cardiac fibroblasts was dependent on Smad3, which suggests that decreased fibrotic remodeling in infarcted Smad3-null hearts may be due to abrogation of the profibrotic transforming growth factor-beta responses."...

PMID:17967972|Circulation. 2007;116:2288-2297
...Cyclic stretch thus increases the abundance of CD40 in endothelial cells through transforming growth factor-beta1/Alk-1 signaling....

PMID:20679547|Circulation. 2010;122:717-728
..."Ang II-mediated myocardial fibrosis and expression of procollagen type I alpha 1, procollagen type III alpha 1, transforming growth factor-beta1, and fibronectin were also suppressed by rhACE2. "...

PMID:20823384|Circulation. 2010;122:1200-1209
..."Histological evaluation of myocardial tissues derived from aged PAI-1-deficient mice revealed myocardial fibrosis resulting from excessive accumulation of collagen. Immunohistochemical characterization revealed that the levels of matrix metalloproteinase-2, matrix metalloproteinase-9, and transforming growth factor-β1/2 and the number of Mac3-positive and fibroblast specific protein-1-positive cells were significantly elevated in aged PAI-1-deficient myocardial tissues compared with controls."...

PMID:21282499|Circulation. 2011;123:584-593
...Omega-3 fatty acids prevent cardiac fibrosis and cardiac dysfunction by blocking transforming growth factor-β1-induced phospho-Smad2/3 nuclear translocation through activation of the cyclic GMP/protein kinase G pathway in cardiac fibroblasts....

PMID:19139386|Circulation. 2009;119:426-435
...Treatment of Apoe(-/-)/Cxcl10(-/-) mice with anti-transforming growth factor-beta neutralizing antibody diminished angiotensin II-induced aortic dilation....

[All Refs in Pubmed]



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