Basic Informations of Metalloproteinase inhibitor 2

Entrez Gene ID: 21858 [Pubmed]

UniProt Protein Name: Metalloproteinase inhibitor 2

UniProt ID: P25785


Related Drug:

No Related Drugs

References

PMID:16702468|Circulation. 2006;113:2435-2444
..." Overexpression of TIMP-2 but not TIMP-1 inhibits atherosclerotic plaque development and destabilisation, possibly through modulation of macrophage and foam cell behavior. "...

PMID:17438151|Circulation. 2007;115:2442-2450
..."PARP inhibition promoted an increase in collagen content, potentially through an increase in tissue inhibitor of metalloproteinase-2, and transmigration of smooth muscle cells to intima of atherosclerotic plaques as well as a decrease in monocyte chemotactic protein-1 production, all of which are markers of plaque stability. "...

PMID:21986284|Circulation. 2011;124:2094-2105
..."Lack of TIMP2 leads to exacerbated cardiac dysfunction and remodeling after pressure overload because of excess activity of membrane type MMP and loss of integrin β1D, leading to nonuniform ECM remodeling and impaired myocyte-ECM interaction."...

[All Refs in Pubmed]



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