Basic Informations of Vascular endothelial growth factor A

Entrez Gene ID: 22339 [Pubmed]

UniProt Protein Name: Vascular endothelial growth factor A

UniProt ID: Q00731

Related Drug:

DrugBank IDDrug Name
DB03088Pyroglutamic Acid


PMID:17088460|Circulation. 2006;114:2261-2270
..." Moreover, ER alpha contributes to upregulation of vascular endothelial growth factor, revealing possible mechanisms of an effect of E2 on EPC biology. "...

PMID:17420349|Circulation. 2007;115:2178-2187
..."Quantitative reverse-transcription polymerase chain reaction analysis showed increased expression of receptors for advanced glycation end products (RAGE), vascular cell adhesion molecule-1, vascular endothelial growth factor, and connective tissue growth factor."...

PMID:17646578|Circulation. 2007;116:774-781
..."However, the serum vascular endothelial growth factor-A level was significantly increased in PHD2-deficient mice."...

PMID:18040029|Circulation. 2007;116:2818-2829
..."This resulted in a diminished hypoxia response, including decreased stromal cell-derived factor 1 (P<0.005) and vascular endothelial growth factor (P<0.0004). "...

PMID:20176991|Circulation. 2010;121:1104-1112
..."Cholesterol enhanced the messenger RNA expression (quantitative, real-time reverse-transcription polymerase chain reaction) of vascular endothelial growth factor and inhibited Notch1 messenger RNA expression in both ApoE(-/-) and WT EPCs, whereas endothelial nitric oxide synthase messenger RNA expression increased in ApoE(-/-) EPCs and declined in WT EPCs after cholesterol exposure. "...

PMID:18427137|Circulation. 2008;117:2224-2231
...Prolonged survival of hypoxic myocardium was followed by an increase in levels of vascular endothelial growth factor protein and neoangiogenesis....

PMID:18824767|Circulation. 2008;118[suppl 1]:S38–S45
..."The deleterious effects of TNFR2 ablation were associated with a decrease in mRNA and protein levels of SOCS3, STAT3, and vascular endothelial growth factor as well as an increase in myocardial interleukin-1-beta production in female hearts. "...

PMID:19273721|Circulation. 2009;119:1524-1532
...Our data support a critical role for GIT1 in pulmonary vascular development by regulating VEGF-induced PLCgamma and ERK1/2 activation....

PMID:19546390|Circulation. 2009;120:50-59
..." As a consequence, 2 key hypoxia-inducible proangiogenic actors, vascular endothelial growth factor-A and endothelial nitric oxide synthase, were upregulated at the mRNA and protein levels. "...

PMID:19652095|Circulation. 2009;120:617-627
...Mechanistic studies revealed that the effect of RGC-32 on the antiangiogenic response was via attenuating fibroblast growth factor 2 expression and further inhibiting expression of cyclin E without affecting vascular endothelial growth factor and fibroblast growth factor 2 signaling in endothelial cells....

[All Refs in Pubmed]

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