Basic Informations of cGMP-specific 3,5-cyclic phosphodiesterase

Entrez Gene ID: 242202 [Pubmed]

UniProt Protein Name: cGMP-specific 3,5-cyclic phosphodiesterase

UniProt ID: Q8CG03


Related Drug:

DrugBank IDDrug Name
DB08729"5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide"
DB079543-ISOBUTYL-1-METHYLXANTHINE
DB06267Udenafil
DB04272Citric Acid
DB03597Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine
DB01972Guanosine-5'-Monophosphate
DB00975Dipyridamole
DB00862Vardenafil
DB00820Tadalafil
DB00806Pentoxifylline
DB00277Theophylline
DB00203Sildenafil

References

PMID:20308615|Circulation. 2010;121:1474-1483
...Myocardial oxidative stress increases PDE5 expression in the failing heart. ...

PMID:19139381|Circulation. 2009;119:408-416
..."Confocal and immunoelectron microscopy revealed increased PDE5 expression in cardiomyocytes, predominantly localized to Z-bands. At baseline, myocardial cGMP levels, "...

PMID:19752383|Circulation. 2009;120[suppl 1]:S31–S36
...Tadalafil is a novel long-acting inhibitor of phosphodiesterase-5. ...

[All Refs in Pubmed]



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