Basic Informations of Dual specificity mitogen-activated protein kinase kinase 1

Entrez Gene ID: 26395 [Pubmed]

UniProt Protein Name: Dual specificity mitogen-activated protein kinase kinase 1

UniProt ID: P31938

Related Drug:

DrugBank IDDrug Name


PMID:17283256|Circulation. 2007;115:763-772
..."In alpha1ABKO hearts, aortic constriction failed to activate ERK, and in alpha1ABKO myocytes, expression of a constitutively active MEK1 rescued alpha1ABKO myocytes from norepinephrine-induced death"...

PMID:17606840|Circulation. 2007;116:535-544
..."However, eNOS is obligatorily required for the development of the cardioprotective effects of late PC and acts as the trigger of this process by activating the PKC epsilon-MEK-1/2-p44/42 mitogen-activated protein kinase pathway, leading to Ser-727 phosphorylation of STAT1 and STAT3 and consequent upregulation of STAT-dependent genes such as cyclooxygenase-2"...

PMID:20837912|Circulation. 2010;122:S185-S192
..."The former was abrogated in the presence of the phosphatidylinositol 3-kinase inhibitor LY294002, whereas the latter was attenuated by LY294002 and by mitogen-activated protein kinase kinase 1 inhibition with PD98059."...

PMID:18663085|Circulation. 2008;118:731-742
...The impaired insulin signaling was restored by PKCbeta inhibitor or MEK1 inhibitor. ...

[All Refs in Pubmed]

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