Basic Informations of Dual specificity mitogen-activated protein kinase kinase 1

Entrez Gene ID: 26395 [Pubmed]

UniProt Protein Name: Dual specificity mitogen-activated protein kinase kinase 1

UniProt ID: P31938


Related Drug:

DrugBank IDDrug Name
DB08208"2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE"
DB08130"N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine"
DB07101"N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide"
DB07046"2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide"
DB06892"(5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide"
DB03115"5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzamide"
DB02152K-252a

References

PMID:17283256|Circulation. 2007;115:763-772
..."In alpha1ABKO hearts, aortic constriction failed to activate ERK, and in alpha1ABKO myocytes, expression of a constitutively active MEK1 rescued alpha1ABKO myocytes from norepinephrine-induced death"...

PMID:17606840|Circulation. 2007;116:535-544
..."However, eNOS is obligatorily required for the development of the cardioprotective effects of late PC and acts as the trigger of this process by activating the PKC epsilon-MEK-1/2-p44/42 mitogen-activated protein kinase pathway, leading to Ser-727 phosphorylation of STAT1 and STAT3 and consequent upregulation of STAT-dependent genes such as cyclooxygenase-2"...

PMID:20837912|Circulation. 2010;122:S185-S192
..."The former was abrogated in the presence of the phosphatidylinositol 3-kinase inhibitor LY294002, whereas the latter was attenuated by LY294002 and by mitogen-activated protein kinase kinase 1 inhibition with PD98059."...

PMID:18663085|Circulation. 2008;118:731-742
...The impaired insulin signaling was restored by PKCbeta inhibitor or MEK1 inhibitor. ...

[All Refs in Pubmed]



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