Basic Informations of Mitogen-activated protein kinase kinase kinase 5

Entrez Gene ID: 26408 [Pubmed]

UniProt Protein Name: Mitogen-activated protein kinase kinase kinase 5

UniProt ID: O35099


Related Drug:

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References

PMID:17562954|Circulation. 2007;115:3197-3204
..."Furthermore, the activation of apoptosis signal-regulating kinase 1 and its downstream effectors, c-Jun N-terminal kinase and p38 mitogen-activated protein kinase, in the hearts of Gq mice was reduced by long-term E2 treatment. Indeed, E2 (10 nmol/L)-treated cardiomyocytes were much more resistant to angiotensin II-induced apoptosis."...

PMID:18195174|Circulation. 2008;117:545-552
..."The activation of p38, a downstream kinase of ASK1, was suppressed selectively in the swimming-exercised ASK1-/- mice. "...

PMID:19332462|Circulation. 2009;119:1941-1949
..." In addition, the ALDH2 transgene significantly attenuated chronic alcohol intake-induced myocardial fibrosis, protein carbonyl formation, apoptosis, enhanced NADPH oxidase p47(phox) and calcineurin expression, as well as phosphorylation of ASK-1, GSK-3beta, GATA4, and CREB."...

[All Refs in Pubmed]



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