Basic Informations of Mitogen-activated protein kinase 3

Entrez Gene ID: 26417 [Pubmed]

UniProt Protein Name: Mitogen-activated protein kinase 3

UniProt ID: Q63844

Related Drug:

DrugBank IDDrug Name
DB01169Arsenic trioxide


PMID:16735677|Circulation. 2006;113:2589-2597
..."n addition, deletion of Hsp70 genes might induce cardiac dysfunction and development of cardiac hypertrophy through the activation of JNK, p38-MAPK, Raf-1, and ERK."...

PMID:17088456|Circulation. 2006;114:2271-2279
..."This increase in ILK was associated with activation of the Rho family guanine triphosphatases, Rac1 and Cdc42, and known hypertrophic signaling kinases, including extracellular signal-related kinases (ERK1/2) and p70 S6 kinase. "...

PMID:17283256|Circulation. 2007;115:763-772
..."To address the mechanism, we examined alpha1-AR activation of extracellular signal-regulated kinase (ERK). "...

PMID:17606840|Circulation. 2007;116:535-544 details...

PMID:17646584|Circulation. 2007;116:654-663
..."In isolated myocytes, CXCR4 activation by SDF-1alpha resulted in increased phosphorylation of both ERK 1/2 and AKT and decreased phosphorylation of JNK and p38"...

PMID:17967772|Circulation. 2007;116:2148-2156
...Vascular smooth muscle cells cultured from these mice also display enhanced proliferation and mitogen-activated protein kinase activity...

PMID:17967980|Circulation. 2007;116: 2298-2306
...Activation of ERK1/2 was increased in injured PAR-1(-/-) mice compared with wild-type mice; ...

PMID:20679547|Circulation. 2010;122:717-728
..."rhACE2 treatment inhibited Ang II-mediated activation of protein kinase C-alpha and protein kinase C-beta1 protein levels and phosphorylation of the extracellular signal-regulated 1/2, Janus kinase 2, and signal transducer and activator of transcription 3 signaling pathways in wild-type mice."...

PMID:20823384|Circulation. 2010;122:1200-1209
..."The numbers of phosphorylated Smad2-, phosphorylated Smad3-, and phosphorylated ERK1/2 MAPK-, but not pAkt/PKB-, positive cells were significantly increased in PAI-1-deficient myocardial tissues. "...

PMID:21173351|Circulation. 2011;123:53-61
...Inhibitors of ERK and JNK signaling could potentially be used to treat humans with cardiomyopathy caused by LMNA mutations....

PMID:22082679|Circulation. 2011;124:2690-2701
..."These mice showed increased activation of gp130 downstream signaling targets (STAT3, ERK1/2, AKT, and p38) from 15 weeks of age and developed cardiac dysfunction from approximately 25 weeks of age with signs of heart failure."...

PMID:22082679|Circulation. 2011;124:2690-2701 details...

PMID:18316486|Circulation. 2008;117:1423-1435
..."Our results identify Shp2 as the first PTP with a critical role in adult cardiac function, indicate that in the absence of Shp2 cardiac hypertrophy does not occur in response to pressure overload, and demonstrate that the cardioprotective role of Shp2 is mediated via control of both the Erk/MAPK and RhoA signaling pathways."...

PMID:18519848|Circulation. 2008;117:3099-3108
..."Adenovirus-mediated overexpression of Fstl1 protected cultured neonatal rat ventricular myocytes from hypoxia/reoxygenation-induced apoptosis (P<0.01), and this protective effect was dependent on the upregulation of both Akt and ERK activities."...

PMID:18574060|Circulation. 2008;117:3216-3226
..."In addition, HMGB1 inhibition with recombinant HMGB1 box A suggested an involvement of the mitogen-activated protein kinases jun N-terminal kinase and extracellular signal-regulated kinase 1/2, as well as the nuclear transcription factor nuclear factor-kappaB in I/R injury."...

PMID:19273721|Circulation. 2009;119:1524-1532
...Our data support a critical role for GIT1 in pulmonary vascular development by regulating VEGF-induced PLCgamma and ERK1/2 activation....

PMID:19273721|Circulation. 2009;119:1524-1532 details...

PMID:19652091|Circulation. 2009;120:607-616
..."Analysis of molecular signaling events in isolated cardiomyocytes indicated that RASSF1A inhibited extracellular regulated kinase 1/2 activation, likely by blocking the binding of Raf1 to active Ras."...

[All Refs in Pubmed]

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