Basic Informations of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Entrez Gene ID: 30955 [Pubmed]

UniProt Protein Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

UniProt ID: Q9JHG7


Related Drug:

DrugBank IDDrug Name
DB08300"1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine"
DB08059"(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE"
DB07503"(5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE"
DB07335"3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL"
DB07073"5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one"
DB06836N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE
DB068312-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE
DB04769"5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE"
DB04216Quercetin
DB026562-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One
DB02375Myricetin
DB02010Staurosporine

References

PMID:21242482|Circulation. 2011;123:391-399
..."Together, these data demonstrate that, in response to transverse aortic constriction, PI3Kγ contributes to maladaptive remodeling at multiple levels by modulating both cardiac and immune cell functions."...

PMID:18268153|Circulation. 2008;117:1310-1317
..."These data identify PI3Kgamma as a new target in atherosclerosis with the potential to modulate multiple stages of atherosclerotic lesion formation, such as fatty streak constitution, cellular composition, and final fibrous cap establishment."...

PMID:18936328|Circulation. 2008;118:1979-1988
..."Wortmannin, a phosphoinositide 3-kinase inhibitor, attenuated basal phosphorylation of Akt and glycogen synthase kinase-3beta and blocked cardiac protection in Cav-3 OE mice. "...

PMID:19687358|Circulation. 2009;120:774-784
..."The in vivo and in vitro data establish that thrombin-induced signaling via protease-activated receptor-1, phospholipase-Cbeta, phosphoinositide 3-kinase, and nitric oxide in monocytes impairs monocyte transendothelial migration. "...

[All Refs in Pubmed]



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