T2D@ZJU is a knowledgebase integrating 3 levels of connections associated with type 2 diabetes mellitus (T2D), including curated directed connections (CDC) dataset, protein-protein interactions (PPI) dataset and text-mining based relationships (TMR) dataset. We provides a Cytoscape Web based interactive network browser for users to visualize the network relationships between T2D-related entities. Our aim is to create a comprehensive T2D network, which will offer a better understanding of T2D for basic and clinical researchers and hereby facilitate the T2D-related translational research. More...

Main entry point to T2D@ZJU web service

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T2D network

Overview of data and data relationships that are related with T2D.

T2D related Pathways

15 pathways are collected, involving insulin signaling pathway, unfolded protein response pathway, AMPK signaling pathway ...

T2D related biomolecules and chemical molecules

Detail information of biomolecules, chemical molecules, and connections in CDC, PPI and TMR datasets.

Information Statistics

Curated directed connection dataset1078306915
Protein-Protein interaction dataset68914893
Text-mined protein relationship dataset62626716
Computed gene-disease relationships 30232077
T2D related genes2165

Notice: All entities in PPI and TMR dataset are included in CDC dataset.


If you make use of the data presented here, please cite the following article in addition to the primary data sources:

Yang Z, Yang J, Liu W, Wu L, Xing L, Wang Y, et al. T2D@ZJU: a knowledgebase integrating heterogeneous connections associated with type 2 diabetes mellitus. Database : the journal of biological databases and curation. 2013;2013:bat052.

Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

Website using assistance: Jihong Yang (yangjiho123@gmail.com)

Pharmaceutical Informatics Institute, Zhejiang University


Update & News

11/18/2015 "Information Statistics" in Homepage updates.

11/18/2015 Download resouces update.

11/17/2015 "Browse" page has been updated

11/17/2015 Download resouces update.

05/24/2013 "Search" page has been updated

05/24/2013 "T2D network" page has been updated

05/14/2013 Case insensitivity is applied in search function.

03/10/2013 Download resouces update.

03/10/2013 "Information Statistics" in Homepage updates.

03/09/2013 Data from PPI databases has been classified.

03/06/2013 Data from Text mining has been updated.

03/03/2013 Data from PPI database has been updated.

02/20/2013 tdnks to source database, such as "KEGG", "REACTOME" "GENE Ontology", have been made.

12/30/2012 Tips of nodes and tdnks update.

12/24/2012 Download resouces update.

12/24/2012 Homepage updates.

12/22/2012 T2D network updates.

12/21/2012 Another 5 pathways have been added.

09/02/2012 All data resources have been updated.