How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.
The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

    •
  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

    •
  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.

    • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)




    The relationship between mechanical properties of carotid artery and coronary artery disease.
  • Author:"Kim, Su-A;Park, Seong-Mi;Kim, Mi-Na;Kim, Yong-Hyun;Cho, Dong-Hyuk;Ahn, Chul-Min;Hong, Soon Jun;Lim, Do-Sun;Shim, Wan Joo"

  • Published Year:2012

  • Journal:European heart journal cardiovascular Imaging

  • Abstract:"AIMS: Carotid intima-media thickness (CIMT) is a useful indicator of coronary artery disease (CAD). The relation between functional changes of the common carotid artery (CCA) and CAD is unclear. This study investigated the relationship between CCA strain and CIMT in the assessment of CAD. METHODS AND RESULTS: Within a 1-month period, 121 patients underwent coronary angiography and ultrasonography of the CCA. Circumferential strain and strain rate were measured in the left CCA by 2D ultrasonography with a speckle tracking method and CIMT was measured using standard techniques. Adequate images were obtained in 104 patients (59 +/- 11 years, 39 females), of which 46 had CAD. Strain and strain rate were negatively correlated with CIMT and were positively correlated with the number of risk factors. CIMT was significantly higher, and strain and strain rate were significantly lower in the CAD group (OR, 95% CI, P-value, CIMT: 23.23, 2.03-265.30, 0.011; strain: 0.51, 0.31-0.82, 0.006; strain rate: 0.01, 0.00-0.13, 0.001). However, after adjustment for cardiovascular risk factors, only strain and strain rate were significantly associated with CAD (OR, 95% CI, P-value, CIMT: 5.28, 0.28-99.84, 0.267; strain: 0.51, 0.30-0.88, 0.014; strain rate: 0.01, 0.00-0.42, 0.014). CAD severity, assessed by the number of stenosed coronary arteries, was also significantly correlated with strain and strain rate, but was not significantly correlated with CIMT. CONCLUSION: Both CIMT and CCA strain were associated with CAD. CAD severity and extent were correlated with strain and strain rate, but were not correlated with CIMT. The evaluation of mechanical properties of CCA by ultrasonographic 2D strain imaging could therefore be more effective than that by CIMT for the assessment of CAD."

  • 10.1093/ejechocard/jer259

    • |Click to search this paper in PubMed|   | back to gene page|