How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.
The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

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  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

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  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.

    • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: APOC3

    Description: apolipoprotein C-III

    Entrez Gene ID: 345

    SwissProt Acc Number: P02656

    RefSeq: NM_000040

    It was suspected to be CHD related:

    ..apoC-III-rich lipoprotein metabolism and the APOC3 polymorphism have relevant impacts on the CAD risk of MS patents...

    From PMID: 14563827, in Journal J Lipid Res , 2003


    References

    There were 24 potential papers with APOC3 and CHD.

    PMIDTitleJournalsDetails
    23377670 Synergistic effect between lipoprotein lipase and apolipoprotein C3 genes in determining the severity of coronary artery disease.Journal of cardiovascular translational researchMore Details
    22717531 Individual and summed effects of high-risk genetic polymorphisms on recurrent cardiovascular events following ischemic heart disease.AtherosclerosisMore Details
    21712729 APOA4 polymorphism as a risk factor for unfavorable lipid serum profile and depression: a cross-sectional study.Journal of investigative medicine : the official publication of the AmericanMore Details
    21185820 "APOC3 -482C>T polymorphism, circulating apolipoprotein C-III and smoking: interrelation and roles in predicting type-2 diabetes and coronary disease."Clinical biochemistryMore Details
    22054125 Lack of association between apolipoprotein C3 gene polymorphisms and risk of coronary heart disease in a Han population in East China.Lipids in health and diseaseMore Details
    22460246 "Influence of genetic variants in the apolipoprotein A5 and C3 gene on lipids, lipoproteins, and its association with coronary artery disease in Indians."Journal of community geneticsMore Details
    18289550 "Synergistic effects of the apolipoprotein E epsilon3/epsilon2/epsilon4, the cholesteryl ester transfer protein TaqIB, and the apolipoprotein C3 -482 C>T polymorphisms on their association with coronary artery disease."AtherosclerosisMore Details
    19074352 A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection."Science (New York, N.Y.)"More Details
    18801202 Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease.Lipids in health and diseaseMore Details
    17367769 "Association between plasma lipid parameters and APOC3 genotypes in Brazilian subjects: effect of gender, smoking and APOE genotypes."Clinica chimica acta; international journal of clinical chemistryMore Details
    16682041 "The -1131 T>C and S19W APOA5 gene polymorphisms are associated with high levels of triglycerides and apolipoprotein C-III, but not with coronary artery disease: an angiographic study."AtherosclerosisMore Details
    16769999 "Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study."Journal of lipid researchMore Details
    16680034 Genetics of familial combined hyperlipidemia.Current opinion in lipidologyMore Details
    16705465 The contribution of individual and pairwise combinations of SNPs in the APOA1 and APOC3 genes to interindividual HDL-C variability."Journal of molecular medicine (Berlin, Germany)"More Details
    16321685 Impact of APOA5/A4/C3 genetic polymorphisms on lipid variables and cardiovascular disease risk in French men.International journal of cardiologyMore Details
    15869758 Metabolic syndrome in aboriginal Canadians: prevalence and genetic associations.AtherosclerosisMore Details
    16326171 Associations between plasma lipid parameters and APOC3 and APOA4 genotypes in a healthy population are independent of dietary cholesterol intake.AtherosclerosisMore Details
    16125709 SNPs at the APOA5 gene account for the strong association with hypertriglyceridaemia at the APOA5/A4/C3/A1 locus on chromosome 11q23 in the Northern Irish population.AtherosclerosisMore Details
    17032446 "Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans."BMC medical geneticsMore Details
    15576429 "Apolipoprotein C-III, n-3 polyunsaturated fatty acids, and ""insulin-resistant"" T-455C APOC3 gene polymorphism in heart disease patients: example of gene-diet interaction."Clinical chemistryMore Details
    15657615 Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD.European journal of human genetics : EJHGMore Details
    12676816 Apolipoprotein AIV gene variant S347 is associated with increased risk of coronary heart disease and lower plasma apolipoprotein AIV levels.Circulation researchMore Details
    14563827 "Apolipoprotein C-III, metabolic syndrome, and risk of coronary artery disease."Journal of lipid researchMore Details
    12476935 Gene polymorphism and coronary risk factors in Indian population.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 1 unique genes interacted with APOC3. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    UBC Reconstituted Complex19850743 No


    Involved FDA drugs

    There was no drug associated with APOC3