Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)
Website using assistance : Leihong Wu (11019004@zju.edu.cn)
Coronary Heart Disease Research Platform
Description: apolipoprotein B (including Ag(x) antigen)
Entrez Gene ID: 338
SwissProt Acc Number: P04114
RefSeq: NM_000384
It was suspected to be CHD related:
.."Familial hypercholesterolemia (FH), characterized by isolated elevation of plasmatic low-density lipoprotein (LDL) cholesterol and premature coronary heart disease (CHD), is associated with mutations in three major genes: LDL receptor (LDLR), apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin 9 (PCSK9)."..
From PMID: 22244043, in Journal Atherosclerosis. , 2012There were 253 potential papers with APOB and CHD.
| PMID | Title | Journals | Details |
|---|---|---|---|
| 23103135 | "Interpretation of lipoprotein-associated phospholipase A2 levels is influenced by cardiac disease, comorbidities, extension of atherosclerosis and treatments." | International journal of cardiology | More Details |
| 23907036 | The extended abnormalities in lipoprotein metabolism in familial hypercholesterolemia: developing a new framework for future therapies. | International journal of cardiology | More Details |
| 24161333 | "AMG 145, A Monoclonal Antibody Against PCSK9, Facilitates Achievement of NCEP-ATP III LDL-C Goals Among High Risk Patients: An Analysis From the LAPLACE-TIMI 57 Trial." | Journal of the American College of Cardiology | More Details |
| 24094290 | Serum creatinine is associated with coronary disease risk even in the absence of metabolic disorders. | Scandinavian journal of clinical and laboratory investigation | More Details |
| 24045547 | Small-dense LDL cholesterol/large-buoyant LDL cholesterol ratio as an excellent marker for indicating lipodystrophy in HIV-infected patients. | American journal of clinical pathology | More Details |
| 24234650 | Novel functional APOB mutations outside LDL-binding region causing familial hypercholesterolaemia. | Human molecular genetics | More Details |
| 24020867 | "Abdominal obesity with hypertriglyceridaemia, lipoprotein(a) and apolipoprotein A-I determine marked cardiometabolic risk." | European journal of clinical investigation | More Details |
| 23678262 | Association of apolipoprotein b/apolipoprotein A1 ratio and coronary artery stenosis and plaques detected by multi-detector computed tomography in healthy population. | Journal of Korean medical science | More Details |
| 23997648 | Autosomal dominant hypercholesterolemia: needs for early diagnosis and cascade screening in the tunisian population. | Current genomics | More Details |
| 22985435 | Small dense LDL is more susceptible to glycation than more buoyant LDL in Type 2 diabetes. | "Clinical science (London, England : 1979)" | More Details |
| 23672999 | Apolipoprotein E in VLDL and LDL with apolipoprotein C-III is associated with a lower risk of coronary heart disease. | Journal of the American Heart Association | More Details |
| 23653095 | Positive correlation between variants of lipid metabolismrelated genes and coronary heart disease. | Molecular medicine reports | More Details |
| 23520163 | Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 23351581 | "Apolipoproteins A-I, B, and C-III in young adult Cherokee with metabolic syndrome with or without type 2 diabetes." | Journal of clinical lipidology | More Details |
| 23357150 | Cascade plasma filtration during the first year after CABG in patients with hyperlipidemia refractory to statins. | Atherosclerosis. Supplements | More Details |
| 23096223 | "High serum apolipoprotein E determines hypertriglyceridemic dyslipidemias, coronary disease and apoA-I dysfunctionality." | Lipids | More Details |
| 23171143 | Association of paraoxonase1 gene Q192R polymorphism and apolipoprotein B in Asian Indian women with coronary artery disease risk. | Genetic testing and molecular biomarkers | More Details |
| 23701995 | Gender-specific association of coronary artery calcium and lipoprotein parameters: the Heinz Nixdorf Recall Study. | Atherosclerosis | More Details |
| 23477485 | "The potential of mipomersen, an ApoB synthesis inhibitor, to reduce necessity for LDL-apheresis in patients with heterozygous familial hypercholesterolemia and coronary artery disease." | Expert opinion on pharmacotherapy | More Details |
| 23584084 | Dyslipidemia in obesity: mechanisms and potential targets. | Nutrients | More Details |
| 23375686 | Spectrum of mutations and phenotypic expression in patients with autosomal dominant hypercholesterolemia identified in Italy. | Atherosclerosis | More Details |
| 23369702 | The effect of LDLR-negative genotype on CT coronary atherosclerosis in asymptomatic statin treated patients with heterozygous familial hypercholesterolemia. | Atherosclerosis | More Details |
| 23422241 | Update on the detection and treatment of atherogenic low-density lipoproteins. | "Current opinion in endocrinology, diabetes, and obesity" | More Details |
| 24151447 | Scavenger receptor class B type 1 gene rs5888 single nucleotide polymorphism and the risk of coronary artery disease and ischemic stroke: a case-control study. | International journal of medical sciences | More Details |
| 23555769 | Elevated PLA2G7 gene promoter methylation as a gender-specific marker of aging increases the risk of coronary heart disease in females. | PloS one | More Details |
| 22854712 | Four polymorphisms of cholesteryl ester transfer protein gene and coronary stenosis in a Tunisian population. | "Journal of cardiovascular medicine (Hagerstown, Md.)" | More Details |
| 23109406 | Apolipoproteins do not add prognostic information beyond lipoprotein cholesterol measures among individuals with obesity and insulin resistance syndromes: The ARIC Study. | European journal of preventive cardiology | More Details |
| 21316934 | Phytosterols supplementation decreases plasma small and dense LDL levels in metabolic syndrome patients on a westernized type diet. | "Nutrition, metabolism, and cardiovascular diseases : NMCD" | More Details |
| 23054246 | Use of targeted exome sequencing as a diagnostic tool for Familial Hypercholesterolaemia. | Journal of medical genetics | More Details |
| 22402736 | Diet-induced weight loss in overweight or obese women and changes in high-density lipoprotein levels and function. | "Obesity (Silver Spring, Md.)" | More Details |
| 22883975 | Genetic analysis of familial hypercholesterolaemia in Western Australia. | Atherosclerosis | More Details |
| 23312049 | Attainment of goal/desirable lipid levels in patients with mixed dyslipidemia after 12 weeks of treatment with fenofibric acid and rosuvastatin combination therapy: a pooled analysis of controlled studies. | Journal of clinical lipidology | More Details |
| 22425626 | "Apolipoprotein A-I, apolipoprotein B, high-sensitivity C-reactive protein and severity of coronary artery disease in Tunisian population." | Cardiovascular pathology : the official journal of the Society for Cardiovascular | More Details |
| 22906895 | Meta-analysis of comparison of effectiveness of lowering apolipoprotein B versus low-density lipoprotein cholesterol and nonhigh-density lipoprotein cholesterol for cardiovascular risk reduction in randomized trials. | The American journal of cardiology | More Details |
| 22893714 | "Familial hypercholesterolemia in the danish general population: prevalence, coronary artery disease, and cholesterol-lowering medication." | The Journal of clinical endocrinology and metabolism | More Details |
| 22466652 | Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice. | The Journal of clinical investigation | More Details |
| 22220933 | Sudden cardiac death in young adults: environmental risk factors and genetic aspects of premature atherosclerosis. | Journal of forensic sciences | More Details |
| 22453571 | "Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis." | JAMA : the journal of the American Medical Association | More Details |
| 22244043 | Molecular characterization of familial hypercholesterolemia in Spain. | Atherosclerosis | More Details |
| 21876547 | Cholesterol efflux from macrophages is influenced differentially by plasmas from overweight insulin-sensitive and -resistant subjects. | International journal of obesity (2005) | More Details |
| 22783321 | Coalition of DNA polymorphisms of ApoB and ApoAI genes is related with coronary artery disease in Kazaks. | Journal of geriatric cardiology : JGC | More Details |
| 22500948 | "Consistency of extended-release niacin/laropiprant effects on Lp(a), ApoB, non-HDL-C, Apo A1, and ApoB/ApoA1 ratio across patient subgroups." | "American journal of cardiovascular drugs : drugs, devices, and other" | More Details |
| 22408029 | Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia. | European heart journal | More Details |
| 22911176 | Role of lipid apheresis in changing times. | Clinical research in cardiology supplements | More Details |
| 22224712 | Exploring the value of apoB48 as a marker for atherosclerosis in clinical practice. | European journal of clinical investigation | More Details |
| 22228254 | Screening for familial hypercholesterolaemia. | Pathology | More Details |
| 22017319 | Management of familial hypercholesterolaemia in children and adolescents. | Journal of paediatrics and child health | More Details |
| 22698793 | The molecular basis of familial hypercholesterolemia in the Czech Republic: spectrum of LDLR mutations and genotype-phenotype correlations. | Atherosclerosis | More Details |
| 21913916 | Erythrocyte-associated apolipoprotein B and its relationship with clinical and subclinical atherosclerosis. | European journal of clinical investigation | More Details |
| 23130121 | Apolipoprotein C-III as a Potential Modulator of the Association Between HDL-Cholesterol and Incident Coronary Heart Disease. | Journal of the American Heart Association | More Details |
| 22301884 | Antisense inhibition of apoB synthesis with mipomersen reduces plasma apoC-III and apoC-III-containing lipoproteins. | Journal of lipid research | More Details |
| 23173569 | Identification of the HDL-ApoCIII to VLDL-ApoCIII ratio as a predictor of coronary artery disease in the general population: the Chin-Shan Community Cardiovascular Cohort (CCCC) study in Taiwan. | Lipids in health and disease | More Details |
| 23028747 | Prediction of risk factors for coronary heart disease using Framingham Risk Score in Korean men. | PloS one | More Details |
| 22479428 | Achieving secondary prevention low-density lipoprotein particle concentration goals using lipoprotein cholesterol-based data. | PloS one | More Details |
| 23067240 | Chromosome 1p13 genetic variants antagonize the risk of myocardial infarction associated with high ApoB serum levels. | BMC cardiovascular disorders | More Details |
| 22111029 | Premature coronary artery disease and familial hypercholesterolemia: need for early diagnosis and cascade screening in the Indian population. | Cardiology research and practice | More Details |
| 22834788 | Hsp70-2 gene polymorphism: susceptibility implication in Tunisian patients with coronary artery disease. | Diagnostic pathology | More Details |
| 23226021 | Mipomersen and other therapies for the treatment of severe familial hypercholesterolemia. | Vascular health and risk management | More Details |
| 24175066 | Normal levels of inflammatory markers in treated patients with familial hypercholesterolaemia: a cross-sectional study. | JRSM cardiovascular disease | More Details |
| 21640348 | "Effect of a traditional Mediterranean diet on apolipoproteins B, A-I, and their ratio: a randomized, controlled trial." | Atherosclerosis | More Details |
| 21663566 | Determinants of blood levels of some thrombogenic biomarkers in healthy Arab adolescent subjects. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 21986282 | Low-density lipoproteins containing apolipoprotein C-III and the risk of coronary heart disease. | Circulation | More Details |
| 22152282 | Pitavastatin: novel effects on lipid parameters. | Atherosclerosis. Supplements | More Details |
| 21889313 | Chlamydia pneumoniae heat shock protein 60 is associated with apoptotic signaling pathway in human atheromatous plaques of coronary artery disease patients. | Journal of cardiology | More Details |
| 21939649 | Combined use of high-sensitivity C-reactive protein and apolipoprotein B/apolipoprotein A-1 ratio prior to elective coronary angiography and oral glucose tolerance tests. | Clinical biochemistry | More Details |
| 21862702 | "Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk." | Journal of lipid research | More Details |
| 21394030 | Association of the serum apolipoprotein levels with the occurrence of coronary vasospasm. | Coronary artery disease | More Details |
| 21310417 | An APEX-based genotyping microarray for the screening of 168 mutations associated with familial hypercholesterolemia. | Atherosclerosis | More Details |
| 21532853 | Apolipoprotein B is highly associated with the risk of coronary heart disease as estimated by the Framingham risk score in healthy Korean men. | Journal of Korean medical science | More Details |
| 21398511 | siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids. | Journal of lipid research | More Details |
| 21860704 | Implications of discoveries from genome-wide association studies in current cardiovascular practice. | World journal of cardiology | More Details |
| 21777740 | Non-high-density lipoprotein cholesterol versus apolipoprotein B in cardiovascular risk stratification: do the math. | Journal of the American College of Cardiology | More Details |
| 20223535 | Independent and additive predictive value of total cholesterol content of erythrocyte membranes with regard to coronary artery disease clinical presentation. | International journal of cardiology | More Details |
| 23554700 | ApoB/apoA1 is an effective predictor of coronary heart disease risk in overweight and obesity. | Journal of biomedical research | More Details |
| 21657943 | "Familial hypercholesterolemia: epidemiology, Neolithic origins and modern geographic distribution." | Critical reviews in clinical laboratory sciences | More Details |
| 21257006 | Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitus. | The American journal of cardiology | More Details |
| 20868450 | On-treatment lipoprotein components and risk of cerebrovascular events in the Treating to New Targets study. | European journal of clinical investigation | More Details |
| 20708914 | Association of apolipoprotein A5 gene polymorphisms and serum lipid levels. | "Nutrition, metabolism, and cardiovascular diseases : NMCD" | More Details |
| 21957197 | "Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure." | Journal of lipid research | More Details |
| 24052710 | "Role of the APOB Gene Polymorphism (c.12669G>A, p. Gln4154Lys) in Coronary Artery Disease in the Indian Punjabi Population." | Balkan journal of medical genetics : BJMG | More Details |
| 21878044 | "Why, when and how should hypertriglyceridemia be treated in the high-risk cardiovascular patient?" | Expert review of cardiovascular therapy | More Details |
| 21484527 | Abnormal lipoprotein(a) levels predict coronary artery calcification in Southeast Asians but not in Caucasians: use of noninvasive imaging for evaluation of an emerging risk factor. | Journal of cardiovascular translational research | More Details |
| 21078622 | Conventional and Mendelian randomization analyses suggest no association between lipoprotein(a) and early atherosclerosis: the Young Finns Study. | International journal of epidemiology | More Details |
| 21117970 | Effects of coadministered ezetimibe plus fenofibrate in mixed dyslipidemic patients with metabolic syndrome. | Metabolic syndrome and related disorders | More Details |
| 21247457 | Genetic variant of V825I in the ATP-binding cassette transporter A1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. | Lipids in health and disease | More Details |
| 21633520 | Cascade Screening for Familial Hypercholesterolemia (FH). | PLoS currents | More Details |
| 21966218 | The effect of the addition of resistance training to a dietary education intervention on apolipoproteins and diet quality in overweight and obese older adults. | Clinical interventions in aging | More Details |
| 21521522 | Impact of sphingomyelin levels on coronary heart disease and left ventricular systolic function in humans. | Nutrition & metabolism | More Details |
| 20667056 | A multimarker approach for the prediction of coronary artery disease: cost-effectiveness analysis. | Value in health : the journal of the International Society for Pharmacoeconomics | More Details |
| 20498921 | "APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men." | "Molecular medicine (Cambridge, Mass.)" | More Details |
| 20736250 | A double heterozygote for familial hypercholesterolaemia and familial defective apolipoprotein B-100. | Annals of clinical biochemistry | More Details |
| 20560981 | The effect of fenofibrate on HDL cholesterol and HDL particle concentration in postmenopausal women on tibolone therapy. | Clinical endocrinology | More Details |
| 20828696 | Update of the Portuguese Familial Hypercholesterolaemia Study. | Atherosclerosis | More Details |
| 21059979 | Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish. | Archives of internal medicine | More Details |
| 20864672 | Genetic variants influencing circulating lipid levels and risk of coronary artery disease. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 20019594 | Novel mutations identification in exon 4 of LDLR gene in patients with moderate hypercholesterolemia in a Venezuelan population. | American journal of therapeutics | More Details |
| 20413364 | Cardiovascular computed tomographic assessment of the effect of combination lipoprotein therapy on coronary arterial plaque: rationale and design of the AFRICA (Atorvastatin plus Fenofibric acid in the Reduction of Intermediate Coronary Atherosclerosis) study. | Journal of cardiovascular computed tomography | More Details |
| 20144596 | Moderate phenotypic expression of familial hypercholesterolemia in Tunisia. | Clinica chimica acta; international journal of clinical chemistry | More Details |
| 20018285 | Pseudoxanthoma elasticum and familial hypercholesterolemia: a deleterious combination of cardiovascular risk factors. | Atherosclerosis | More Details |
| 19800772 | Cardiovascular disease prevalence and its relation to risk factors in Alaska Eskimos. | "Nutrition, metabolism, and cardiovascular diseases : NMCD" | More Details |
| 20102908 | Relation of change in apolipoprotein B/apolipoprotein A-I ratio to coronary plaque regression after Pravastatin treatment in patients with coronary artery disease. | The American journal of cardiology | More Details |
| 19923980 | Impact of genetic polymorphisms on platelet function and aspirin resistance. | Blood coagulation & fibrinolysis : an international journal in haemostasis and | More Details |
| 20152239 | "Relation of oxidative biomarkers, vascular dysfunction, and progression of coronary artery calcium." | The American journal of cardiology | More Details |
| 19965785 | Identification of two common variants contributing to serum apolipoprotein B levels in Mexicans. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 20715976 | Integrated role of two apoliprotein E polymorphisms on apolipoprotein B levels and coronary artery disease in a biethnic population. | Metabolic syndrome and related disorders | More Details |
| 20715933 | Apolipoprotein B and non-high-density lipoprotein cholesterol are better risk markers for coronary artery disease than low-density lipoprotein cholesterol in hypertriglyceridemic metabolic syndrome patients. | Metabolic syndrome and related disorders | More Details |
| 20217239 | Identification of a recurrent insertion mutation in the LDLR gene in a Pakistani family with autosomal dominant hypercholesterolemia. | Molecular biology reports | More Details |
| 20842562 | Do We Know When and How to Lower Lipoprotein(a)? | Current treatment options in cardiovascular medicine | More Details |
| 20517165 | Apolipoprotein C-III gene polymorphism and several environmental factors with serum lipid levels in the Guangxi Hei Yi Zhuang and Han populations. | Journal of investigative medicine : the official publication of the American | More Details |
| 19959168 | Changes in the atherogenic profile of patients with type 1 Gaucher disease after miglustat therapy. | Atherosclerosis | More Details |
| 19880117 | The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. | Atherosclerosis | More Details |
| 20334678 | PPARgamma gene C161T substitution alters lipid profile in Chinese patients with coronary artery disease and type 2 diabetes mellitus. | Cardiovascular diabetology | More Details |
| 20395681 | High absolute coronary disease risk among Turks: involvement of risk factors additional to conventional ones. | Cardiology | More Details |
| 23105865 | Relationship between PON1L55M and Q192R gene polymorphisms and high APO B/APO A-I ratios. | Indian journal of clinical biochemistry : IJCB | More Details |
| 18676970 | Concentration of apolipoprotein B is comparable with the apolipoprotein B/apolipoprotein A-I ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality: findings from a multi-ethnic US population. | European heart journal | More Details |
| 19217510 | Advanced lipoprotein testing: recommendations based on current evidence. | Endocrinology and metabolism clinics of North America | More Details |
| 19497447 | "Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial." | Journal of the American College of Cardiology | More Details |
| 21152377 | The common apolipoprotein A-1 polymorphism -75A>G is associated with ethnic differences in recurrent coronary events after recovery from an acute myocardial infarction. | Heart international | More Details |
| 19336475 | Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. | Human molecular genetics | More Details |
| 19269283 | Association of homocysteine thiolactonase activity and PON1 polymorphisms with the severity of acute coronary syndrome. | Clinical biochemistry | More Details |
| 19252179 | ApoE and ApoC-I polymorphisms: association of genotype with cardiovascular disease phenotype in African Americans. | Journal of lipid research | More Details |
| 19319977 | The molecular basis of familial hypercholesterolemia in Lebanon: spectrum of LDLR mutations and role of PCSK9 as a modifier gene. | Human mutation | More Details |
| 19041195 | [Familial hypercholesterolemia in Tunisia]. | Pathologie-biologie | More Details |
| 18851956 | ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment. | Biochemical pharmacology | More Details |
| 18648394 | LDLR promoter variant and exon 14 mutation on the same chromosome are associated with an unusually severe FH phenotype and treatment resistance. | European journal of human genetics : EJHG | More Details |
| 18511055 | Glycation of LDL in non-diabetic people: Small dense LDL is preferentially glycated both in vivo and in vitro. | Atherosclerosis | More Details |
| 19155782 | The environmental and genetic evidence for the association of hyperlipidemia and hypertension. | Journal of hypertension | More Details |
| 19642911 | Body mass and atherogenic dyslipidemia as major determinants of blood levels of B-type natriuretic peptides in Arab subjects with acute coronary syndromes. | Metabolic syndrome and related disorders | More Details |
| 19501926 | The comparison of coronary angiographic profiles between diabetic and nondiabetic patients with coronary artery disease in a Chinese population. | Diabetes research and clinical practice | More Details |
| 19327776 | Congestive heart failure is associated with lipoprotein components in statin-treated patients with coronary heart disease Insights from the Incremental Decrease in End points Through Aggressive Lipid Lowering Trial (IDEAL). | Atherosclerosis | More Details |
| 19491209 | Apolipoprotein B but not LDL cholesterol is associated with coronary artery calcification in type 2 diabetic whites. | Diabetes | More Details |
| 19222610 | Lipid-altering efficacy of ezetimibe/simvastatin 10/20 mg compared with rosuvastatin 10 mg in high-risk hypercholesterolaemic patients inadequately controlled with prior statin monotherapy - The IN-CROSS study. | International journal of clinical practice | More Details |
| 21637672 | "Effects of APOE, APOB and LDLR variants on serum lipids and lack of association with xanthelasma in individuals from Southeastern Brazil." | Genetics and molecular biology | More Details |
| 19494537 | "Apolipoprotein E, CI and B gene polymorphisms in a sample of patients with coronary heart disease in the Kuwaiti population." | "Medical principles and practice : international journal of the Kuwait University," | More Details |
| 19948027 | Plasma PLTP activity is inversely associated with HDL-C levels. | Nutrition & metabolism | More Details |
| 18490703 | Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies. | Journal of lipid research | More Details |
| 18922385 | Association of low-density lipoprotein particle size and ratio of different lipoproteins and apolipoproteins with coronary heart disease. | Journal of cardiology | More Details |
| 17462871 | Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease. | "Nutrition, metabolism, and cardiovascular diseases : NMCD" | More Details |
| 18325181 | High-resolution melting analysis for detection of familial ligand-defective apolipoprotein B-100 mutations. | Annals of clinical biochemistry | More Details |
| 18279815 | Evaluation of clinical diagnosis criteria of familial ligand defective apoB 100 and lipoprotein phenotype comparison between LDL receptor gene mutations affecting ligand-binding domain and the R3500Q mutation of the apoB gene in patients from a South European population. | Translational research : the journal of laboratory and clinical medicine | More Details |
| 18096825 | Femoral atherosclerosis in heterozygous familial hypercholesterolemia: influence of the genetic defect. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 18355452 | A novel splice site mutation of the LDL receptor gene in a Tunisian hypercholesterolemic family. | Clinica chimica acta; international journal of clinical chemistry | More Details |
| 18640459 | "Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study." | Lancet | More Details |
| 18261682 | "High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A-I: significance for cardiovascular risk: the IDEAL and EPIC-Norfolk studies." | Journal of the American College of Cardiology | More Details |
| 18193043 | Newly identified loci that influence lipid concentrations and risk of coronary artery disease. | Nature genetics | More Details |
| 19041816 | [Decrease ApoB/ApoA-1 ratio and cardiovascular risk improvement: a tadalafil pleiotropic effect? Preliminary study on healthy volunteers]. | Progres en urologie : journal de l'Association francaise d'urologie et de la | More Details |
| 18702965 | Statin therapy alters the relationship between apolipoprotein B and low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol targets in high-risk patients: the MERCURY II (Measuring Effective Reductions in Cholesterol Using Rosuvastatin) trial. | Journal of the American College of Cardiology | More Details |
| 21291725 | "Effect of ezetimibe/simvastatin versus atorvastatin or rosuvastatin on modifying lipid profiles in patients with diabetes, metabolic syndrome, or neither: Results of two subgroup analyses." | Journal of clinical lipidology | More Details |
| 18221422 | Glycemic control in adolescents with type 1 diabetes mellitus improves lipid serum levels and oxidative stress. | Pediatric diabetes | More Details |
| 18333887 | The contribution of ApoB and ApoA1 measurements to cardiovascular risk assessment. | "Diabetes, obesity & metabolism" | More Details |
| 18925970 | Taurine reduces the secretion of apolipoprotein B100 and lipids in HepG2 cells. | Lipids in health and disease | More Details |
| 18590467 | Association of the insertion/deletion gene polymorphism of the apolipoprotein B signal peptide with myocardial infarction in Tunisian patients. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 18254714 | 5' ins/del and 3' VNTR polymorphisms in the apolipoprotein B gene in relation to lipids and coronary artery disease. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 18598204 | "Interactions of lipoprotein(a) with diabetes mellitus, apolipoprotein B and cholesterol enhance the prognostic values for coronary artery disease." | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 18801202 | Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease. | Lipids in health and disease | More Details |
| 19012525 | Aggregation of lipoprotein and inflammatory parameters in families with a history of premature myocardial infarction: the Tallinn myocardial infarction study. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 18609106 | Role of the fractalkine receptor CX3CR1 polymorphisms V249I and T280M as risk factors for early-onset coronary artery disease in patients with no classic risk factors. | Scandinavian journal of clinical and laboratory investigation | More Details |
| 17403027 | The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk. | Annals of human genetics | More Details |
| 17094996 | Genetic defects causing familial hypercholesterolaemia: identification of deletions and duplications in the LDL-receptor gene and summary of all mutations found in patients attending the Hammersmith Hospital Lipid Clinic. | Atherosclerosis | More Details |
| 18066136 | "Modulation of apolipoprotein A1 and B, adiponectin, ghrelin, and growth hormone concentrations by plant sterols and exercise in previously sedentary humans." | Canadian journal of physiology and pharmacology | More Details |
| 17964036 | Beyond low-density lipoprotein cholesterol: defining the role of low-density lipoprotein heterogeneity in coronary artery disease. | Journal of the American College of Cardiology | More Details |
| 17964958 | LDLR and ApoB are major genetic causes of autosomal dominant hypercholesterolemia in a Taiwanese population. | Journal of the Formosan Medical Association = Taiwan yi zhi | More Details |
| 17845895 | Plasma protein lipofuscin-like fluorophores in men with coronary artery disease treated with statins. | Archives of medical research | More Details |
| 17719023 | Development of new enzyme-linked immunosorbent assay for oxidized lipoprotein(a) by using purified human oxidized lipoprotein(a) autoantibodies as capture antibody. | Clinica chimica acta; international journal of clinical chemistry | More Details |
| 17955342 | Hyperlipoproteinaemia(a) is a common cause of autosomal dominant hypercholesterolaemia. | Journal of inherited metabolic disease | More Details |
| 17652266 | Diabetes and arterial extracellular matrix changes in a porcine model of atherosclerosis. | The journal of histochemistry and cytochemistry : official journal of the | More Details |
| 17698856 | Apolipoprotein B and non-high density lipoprotein cholesterol and the risk of coronary heart disease in Chinese. | Journal of lipid research | More Details |
| 17525004 | PON1 activity is inversely related to LDL apoB carbonyl content in patients with coronary artery disease. | The Kaohsiung journal of medical sciences | More Details |
| 17393220 | Postprandial lipemia is modified by the presence of the APOB-516C/T polymorphism in a healthy Caucasian population. | Lipids | More Details |
| 17103149 | Quantification of serum apolipoprotein B by infrared spectroscopy. | Analytical and bioanalytical chemistry | More Details |
| 16682089 | The applicability of the Asian modified criteria of the metabolic syndrome in the Korean population. | International journal of cardiology | More Details |
| 16797745 | Associations of apolipoprotein B with pulse pressure and glucose in Chinese families with familial combined hyperlipidemia. | International journal of cardiology | More Details |
| 16730731 | Redox-sensitive impairment of porcine coronary artery vasodilation by hypochlorite-modified LDL. | Atherosclerosis | More Details |
| 17227233 | MTP inhibition as a treatment for dyslipidaemias: time to deliver or empty promises? | Expert opinion on therapeutic targets | More Details |
| 17890784 | Evidence for a quantitative trait locus affecting low levels of apolipoprotein B and low density lipoprotein on chromosome 10 in Caucasian families. | Journal of lipid research | More Details |
| 17588826 | Establishing the benefit of statins in low-to-moderate--risk primary prevention: the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS). | Atherosclerosis. Supplements | More Details |
| 16677656 | Do allelic variants of the connexin37 1019 gene polymorphism differentially predict for coronary artery disease and myocardial infarction? | Atherosclerosis | More Details |
| 17380167 | Mechanisms of disease: genetic causes of familial hypercholesterolemia. | Nature clinical practice. Cardiovascular medicine | More Details |
| 16792510 | Molecular genetic testing for familial hypercholesterolemia in the Netherlands: a stepwise screening strategy enhances the mutation detection rate. | Genetic testing | More Details |
| 16949489 | "Is plasma oxidized low-density lipoprotein, measured with the widely used antibody 4E6, an independent predictor of coronary heart disease among U.S. men and women?" | Journal of the American College of Cardiology | More Details |
| 16712524 | Body composition and the apoB/apoA-I ratio in migrant Asian Indians and white Caucasians in Canada. | "Clinical science (London, England : 1979)" | More Details |
| 16963013 | "Interactions of serum hsCRP with apoB, apoB/AI ratio and some components of metabolic syndrome amplify the predictive values for coronary artery disease." | Clinical biochemistry | More Details |
| 16384561 | Efficacy and tolerability of combined treatment with L-carnitine and simvastatin in lowering lipoprotein(a) serum levels in patients with type 2 diabetes mellitus. | Atherosclerosis | More Details |
| 16504986 | Apolipoproteins as markers and managers of coronary risk. | QJM : monthly journal of the Association of Physicians | More Details |
| 16751940 | [Lipid profile and nutrition counseling effects in adolescents with family history of premature coronary artery disease]. | Arquivos brasileiros de cardiologia | More Details |
| 16629854 | "Associations between apolipoprotein B, apolipoprotein AI, the apolipoprotein B/AI ratio and coronary heart disease: a literature-based meta-analysis of prospective studies." | Journal of internal medicine | More Details |
| 16389549 | "Mutational analysis in UK patients with a clinical diagnosis of familial hypercholesterolaemia: relationship with plasma lipid traits, heart disease risk and utility in relative tracing." | "Journal of molecular medicine (Berlin, Germany)" | More Details |
| 19804074 | "The effects of apoA-I/C-III/A-IV, apoE and apoB polymorphisms on carotid artery intima-media thickness." | Future cardiology | More Details |
| 16487434 | Short-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects. | Clinical endocrinology | More Details |
| 16154574 | Modulating effects of cholesterol feeding and simvastatin treatment on platelet-activating factor acetylhydrolase activity and lysophosphatidylcholine concentration. | Atherosclerosis | More Details |
| 16752182 | Apolipoprotein B: a predictor of inflammatory status in postmenopausal overweight and obese women. | Diabetologia | More Details |
| 16843720 | Fatty acids bound to human serum albumin and its structural variants modulate apolipoprotein B secretion in HepG2 cells. | Biochimica et biophysica acta | More Details |
| 16617174 | The Ile128Thr polymorphism influences stability and ligand binding properties of the microsomal triglyceride transfer protein. | Journal of lipid research | More Details |
| 16461842 | Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells. | Circulation | More Details |
| 16322531 | Increased apolipoprotein deposits in early atherosclerotic lesions distinguish symptomatic from asymptomatic patients. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 17142622 | Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk. | Journal of medical genetics | More Details |
| 17087781 | Identification and characterization of novel low-density lipoprotein receptor mutations of familial hypercholesterolaemia patients in Taiwan. | European journal of clinical investigation | More Details |
| 16990559 | Relationship between lipid abnormalities and insulin resistance in Japanese school children. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 16763159 | Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 16477380 | "Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice." | Molecular and cellular biochemistry | More Details |
| 16396678 | Further evaluation of plasma sphingomyelin levels as a risk factor for coronary artery disease. | Nutrition & metabolism | More Details |
| 17032131 | Apolipoprotein B gene 3'VNTR polymorphism: association with plasma lipids and coronary heart disease in Han Chinese. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 16879071 | "The ratio of apoB/apoAI, apoB and lipoprotein(a) are the best predictors of stable coronary artery disease." | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 16375584 | "Serum calcium and phosphorus associate with the occurrence and severity of angiographically documented coronary heart disease, possibly through correlation with atherogenic (apo)lipoproteins." | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 16159606 | Genetic screening protocol for familial hypercholesterolemia which includes splicing defects gives an improved mutation detection rate. | Atherosclerosis | More Details |
| 16015283 | Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions. | European journal of human genetics : EJHG | More Details |
| 16291017 | Pharmacogenomics of statin responsiveness. | The American journal of cardiology | More Details |
| 16316964 | Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in men. | Circulation | More Details |
| 16386541 | Effect of apolipoprotein B polymorphism in kidney transplantation. | Transplantation proceedings | More Details |
| 16266403 | The association of mitochondrial DNA 5178 C > a polymorphism with plasma lipid levels among three ethnic groups. | Annals of human genetics | More Details |
| 15741053 | Trans fatty acids alter the lipid composition and size of apoB-100-containing lipoproteins secreted by HepG2 cells. | The Journal of nutritional biochemistry | More Details |
| 16004894 | Prognostic value of lipoproteins and their relation to inflammatory markers among patients with coronary artery disease. | International journal of cardiology | More Details |
| 15690311 | ApoC-III bound to apoB-containing lipoproteins increase with insulin resistance in Cherokee Indian youth. | Metabolism: clinical and experimental | More Details |
| 16195894 | Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks. | Human genetics | More Details |
| 16250003 | Update of the molecular basis of familial hypercholesterolemia in The Netherlands. | Human mutation | More Details |
| 15777551 | Differences between markers of atherogenic lipoproteins in predicting high cardiovascular risk and subclinical atherosclerosis in asymptomatic men. | Atherosclerosis | More Details |
| 16390683 | Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism. | Critical reviews in clinical laboratory sciences | More Details |
| 15321838 | Familial hypercholesterolemia and coronary heart disease: a HuGE association review. | American journal of epidemiology | More Details |
| 15321837 | Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review. | American journal of epidemiology | More Details |
| 15308601 | Lipid disorders and mutations in the APOB gene. | Clinical chemistry | More Details |
| 15099276 | Effects of lipids and lipid-lowering therapy on hemostatic factors in patients with myocardial infarction. | Journal of thrombosis and haemostasis : JTH | More Details |
| 15146369 | Qualitative effect of fenofibrate and quantitative effect of atorvastatin on LDL profile in combined hyperlipidemia with dense LDL. | "Experimental and clinical endocrinology & diabetes : official journal, German" | More Details |
| 15121031 | Insights from apoB: from better diagnosis & therapy to the Medusa Hypothesis. | Atherosclerosis. Supplements | More Details |
| 15181078 | Low-density lipoprotein particle size and its regulatory factors in school children. | The Journal of clinical endocrinology and metabolism | More Details |
| 15222761 | Dioxin alters the human low-density and very low-density lipoprotein structure with evidence for specific quenching of Trp-48 in apolipoprotein C-II. | Biochemistry | More Details |
| 15043507 | Evidence for a complex risk profile in obese postmenopausal Turkish women with hypertriglyceridaemia and elevated apolipoprotein B. | "Clinical science (London, England : 1979)" | More Details |
| 15061377 | Isolation of plasma small-dense low-density lipoprotein using a simple air-driven ultracentrifuge and quantification using immunoassay of apolipoprotein B. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 15571826 | The apolipoprotein E polymorphism is associated with circulating C-reactive protein (the Ludwigshafen risk and cardiovascular health study). | European heart journal | More Details |
| 15523646 | LDL-receptor mutations in Europe. | Human mutation | More Details |
| 15530912 | Apolipoprotein B determines risk for recurrent coronary events in postinfarction patients with metabolic syndrome. | Atherosclerosis | More Details |
| 15205217 | Circulating oxidized low-density lipoprotein and its association with carotid intima-media thickness in asymptomatic members of familial combined hyperlipidemia families. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 15630635 | Familial defective apolipoprotein B versus familial hypercholesterolemia: an assessment of risk. | Seminars in vascular medicine | More Details |
| 14729863 | "APOA5 gene variants, lipoprotein particle distribution, and progression of coronary heart disease: results from the LOCAT study." | Journal of lipid research | More Details |
| 15543563 | Five polymorphisms in gene candidates for cardiovascular disease in Afro-Brazilian individuals. | Journal of clinical laboratory analysis | More Details |
| 15576296 | The apoB/apoA-I ratio is better than the cholesterol ratios to estimate the balance between plasma proatherogenic and antiatherogenic lipoproteins and to predict coronary risk. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 12964943 | "Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD." | BMC medical genetics | More Details |
| 12958176 | Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion. | FASEB journal : official publication of the Federation of American Societies for | More Details |
| 12897184 | "A novel and simple method for quantification of small, dense LDL." | Journal of lipid research | More Details |
| 12637336 | LDL containing apolipoprotein CIII is an independent risk factor for coronary events in diabetic patients. | "Arteriosclerosis, thrombosis, and vascular biology" | More Details |
| 15030301 | Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders. | Expert review of cardiovascular therapy | More Details |
| 12730697 | Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. | Nature genetics | More Details |
| 12835223 | Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis. | Circulation | More Details |
| 12709788 | ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore. | Human genetics | More Details |
| 12700893 | The association of the R219K polymorphism in the ATP-binding cassette transporter 1 ( ABCA1) gene with coronary heart disease and hyperlipidaemia. | "Journal of molecular medicine (Berlin, Germany)" | More Details |
| 12890925 | Pleiotropy and heterogeneity in the expression of atherogenic lipoproteins: the IRAS Family Study. | Human heredity | More Details |
| 12436350 | "Effects of SREBF-1a and SCAP polymorphisms on plasma levels of lipids, severity, progression and regression of coronary atherosclerosis and response to therapy with fluvastatin." | "Journal of molecular medicine (Berlin, Germany)" | More Details |
| 11902853 | Vitamin C intake and apolipoproteins in a healthy elderly Japanese population. | Preventive medicine | More Details |
| 12378047 | "Comparison of the effects of dietary saturated, mono-, and n-6 polyunsaturated fatty acids on blood lipid profile, oxidant stress, prostanoid synthesis and aortic histology in rabbits." | Annals of nutrition & metabolism | More Details |
| 11179013 | Use of homozygosity mapping to identify a region on chromosome 1 bearing a defective gene that causes autosomal recessive homozygous hypercholesterolemia in two unrelated families. | American journal of human genetics | More Details |
| 11230170 | A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation. | Genome research | More Details |
| 11359065 | "Population genetic analysis of the genes APOE, APOB(3'VNTR) and ACE in some black and Amerindian communities from Colombia." | Human heredity | More Details |
| 11096445 | Hammerhead ribozyme as a therapeutic agent for hyperlipidemia: production of truncated apolipoprotein B and hypolipidemic effects in a dyslipidemia murine model. | Human gene therapy | More Details |
| 10873614 | Enhanced secretion of ApoB by transfected HepG2 cells overexpressing fibrinogen. | Biochemical and biophysical research communications | More Details |
NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.
There were totally 41 unique genes interacted with APOB. Show PPI network
| Gene name | Interaction type | reference PMID | CHD relation |
|---|---|---|---|
| MTTP | Two-hybrid | 9915855 | CHD related |
| BGN | Reconstituted Complex | 12070165 | No |
| HSP90B1 | Affinity Capture-Western | 12397072|12397072|9694898 | No |
| PDIA4 | Affinity Capture-Western | 12397072|12397072|9694898 | No |
| CALCR | Affinity Capture-Western | 12397072|12397072|9694898 | No |
| PPIB | Affinity Capture-Western | 12397072|12397072 | No |
| LIPC | Reconstituted Complex | 9685400 | CHD related |
| UBC | Affinity Capture-Western | 15618547|18550891|22238364 | No |
| LRP6 | Reconstituted Complex | 18948618 | CHD related |
| VCP | Affinity Capture-Western | 18550891|19164805 | No |
| APOB | Affinity Capture-Western | 19164805 | CHD related |
| HSPA5 | Affinity Capture-Western | 19164805 | No |
| SYVN1 | Affinity Capture-Western | 19164805 | No |
| DERL1 | Affinity Capture-Western | 19164805 | No |
| SELS | Affinity Capture-Western | 19164805 | CHD related |
| FAF2 | Affinity Capture-Western | 22238364 | No |
| CANX | Affinity Capture-Western | 14498830|14498830 | No |
| SSE1 | Biochemical Activity | 17823116|17823116 | No |
| SEC61 | Affinity Capture-Western | 17823116 | No |
| RPT6 | Biochemical Activity | 17823116 | No |
| KAR2 | Biochemical Activity | 17823116 | No |
| UFD1 | Biochemical Activity | 17823116 | No |
| UBC7 | Biochemical Activity | 17823116 | No |
| SSM4 | Biochemical Activity | 17823116 | No |
| HRD1 | Biochemical Activity | 17823116 | No |
| SSA1 | Affinity Capture-Western | 17823116 | No |
| CALR | Affinity Capture-Western | 10513896|10513896,12397072 | No |
| SEC61A1 | Affinity Capture-Western | 9565615 | No |
| SEC61B | Affinity Capture-Western | 9565615|9565615 | No |
| UCHL5 | Affinity Capture-MS | 21800051 | No |
| PDI1 | Affinity Capture-Western | 22190736 | No |
| SUMO2 | Affinity Capture-MS | 21693764 | No |
| RAD21 | Affinity Capture-Western | 22145905 | No |
| APOA1 | Affinity Capture-Western | 19164805|7592581 | CHD related |
| PLIN2 | Affinity Capture-Western | 22238364 | No |
| HSPA1A | in vitro | 9252351 | CHD related |
| HSP90AA1 | in vitro;in vivo | 11333259 | CHD related |
| LRP2 | in vitro;in vivo | 10330424 | No |
| LDLR | in vivo | 12031600 | CHD related |
| HSPA8 | in vivo | 9694898 | CHD related |
| SEC61A2 | in vivo | 9565615 | No |
There was no drug associated with APOB