How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: APOB

    Description: apolipoprotein B (including Ag(x) antigen)

    Entrez Gene ID: 338

    SwissProt Acc Number: P04114

    RefSeq: NM_000384

    It was suspected to be CHD related:

    .."Familial hypercholesterolemia (FH), characterized by isolated elevation of plasmatic low-density lipoprotein (LDL) cholesterol and premature coronary heart disease (CHD), is associated with mutations in three major genes: LDL receptor (LDLR), apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin 9 (PCSK9)."..

    From PMID: 22244043, in Journal Atherosclerosis. , 2012


    There were 253 potential papers with APOB and CHD.

    23103135 "Interpretation of lipoprotein-associated phospholipase A2 levels is influenced by cardiac disease, comorbidities, extension of atherosclerosis and treatments."International journal of cardiologyMore Details
    23907036 The extended abnormalities in lipoprotein metabolism in familial hypercholesterolemia: developing a new framework for future therapies.International journal of cardiologyMore Details
    24161333 "AMG 145, A Monoclonal Antibody Against PCSK9, Facilitates Achievement of NCEP-ATP III LDL-C Goals Among High Risk Patients: An Analysis From the LAPLACE-TIMI 57 Trial."Journal of the American College of CardiologyMore Details
    24094290 Serum creatinine is associated with coronary disease risk even in the absence of metabolic disorders.Scandinavian journal of clinical and laboratory investigationMore Details
    24045547 Small-dense LDL cholesterol/large-buoyant LDL cholesterol ratio as an excellent marker for indicating lipodystrophy in HIV-infected patients.American journal of clinical pathologyMore Details
    24234650 Novel functional APOB mutations outside LDL-binding region causing familial hypercholesterolaemia.Human molecular geneticsMore Details
    24020867 "Abdominal obesity with hypertriglyceridaemia, lipoprotein(a) and apolipoprotein A-I determine marked cardiometabolic risk."European journal of clinical investigationMore Details
    23678262 Association of apolipoprotein b/apolipoprotein A1 ratio and coronary artery stenosis and plaques detected by multi-detector computed tomography in healthy population.Journal of Korean medical scienceMore Details
    23997648 Autosomal dominant hypercholesterolemia: needs for early diagnosis and cascade screening in the tunisian population.Current genomicsMore Details
    22985435 Small dense LDL is more susceptible to glycation than more buoyant LDL in Type 2 diabetes."Clinical science (London, England : 1979)"More Details
    23672999 Apolipoprotein E in VLDL and LDL with apolipoprotein C-III is associated with a lower risk of coronary heart disease.Journal of the American Heart AssociationMore Details
    23653095 Positive correlation between variants of lipid metabolismrelated genes and coronary heart disease.Molecular medicine reportsMore Details
    23520163 Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks."Arteriosclerosis, thrombosis, and vascular biology"More Details
    23351581 "Apolipoproteins A-I, B, and C-III in young adult Cherokee with metabolic syndrome with or without type 2 diabetes."Journal of clinical lipidologyMore Details
    23357150 Cascade plasma filtration during the first year after CABG in patients with hyperlipidemia refractory to statins.Atherosclerosis. SupplementsMore Details
    23096223 "High serum apolipoprotein E determines hypertriglyceridemic dyslipidemias, coronary disease and apoA-I dysfunctionality."LipidsMore Details
    23171143 Association of paraoxonase1 gene Q192R polymorphism and apolipoprotein B in Asian Indian women with coronary artery disease risk.Genetic testing and molecular biomarkersMore Details
    23701995 Gender-specific association of coronary artery calcium and lipoprotein parameters: the Heinz Nixdorf Recall Study.AtherosclerosisMore Details
    23477485 "The potential of mipomersen, an ApoB synthesis inhibitor, to reduce necessity for LDL-apheresis in patients with heterozygous familial hypercholesterolemia and coronary artery disease."Expert opinion on pharmacotherapyMore Details
    23584084 Dyslipidemia in obesity: mechanisms and potential targets.NutrientsMore Details
    23375686 Spectrum of mutations and phenotypic expression in patients with autosomal dominant hypercholesterolemia identified in Italy.AtherosclerosisMore Details
    23369702 The effect of LDLR-negative genotype on CT coronary atherosclerosis in asymptomatic statin treated patients with heterozygous familial hypercholesterolemia.AtherosclerosisMore Details
    23422241 Update on the detection and treatment of atherogenic low-density lipoproteins."Current opinion in endocrinology, diabetes, and obesity"More Details
    24151447 Scavenger receptor class B type 1 gene rs5888 single nucleotide polymorphism and the risk of coronary artery disease and ischemic stroke: a case-control study.International journal of medical sciencesMore Details
    23555769 Elevated PLA2G7 gene promoter methylation as a gender-specific marker of aging increases the risk of coronary heart disease in females.PloS oneMore Details
    22854712 Four polymorphisms of cholesteryl ester transfer protein gene and coronary stenosis in a Tunisian population."Journal of cardiovascular medicine (Hagerstown, Md.)"More Details
    23109406 Apolipoproteins do not add prognostic information beyond lipoprotein cholesterol measures among individuals with obesity and insulin resistance syndromes: The ARIC Study.European journal of preventive cardiologyMore Details
    21316934 Phytosterols supplementation decreases plasma small and dense LDL levels in metabolic syndrome patients on a westernized type diet."Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    23054246 Use of targeted exome sequencing as a diagnostic tool for Familial Hypercholesterolaemia.Journal of medical geneticsMore Details
    22402736 Diet-induced weight loss in overweight or obese women and changes in high-density lipoprotein levels and function."Obesity (Silver Spring, Md.)"More Details
    22883975 Genetic analysis of familial hypercholesterolaemia in Western Australia.AtherosclerosisMore Details
    23312049 Attainment of goal/desirable lipid levels in patients with mixed dyslipidemia after 12 weeks of treatment with fenofibric acid and rosuvastatin combination therapy: a pooled analysis of controlled studies.Journal of clinical lipidologyMore Details
    22425626 "Apolipoprotein A-I, apolipoprotein B, high-sensitivity C-reactive protein and severity of coronary artery disease in Tunisian population."Cardiovascular pathology : the official journal of the Society for CardiovascularMore Details
    22906895 Meta-analysis of comparison of effectiveness of lowering apolipoprotein B versus low-density lipoprotein cholesterol and nonhigh-density lipoprotein cholesterol for cardiovascular risk reduction in randomized trials.The American journal of cardiologyMore Details
    22893714 "Familial hypercholesterolemia in the danish general population: prevalence, coronary artery disease, and cholesterol-lowering medication."The Journal of clinical endocrinology and metabolismMore Details
    22466652 Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice.The Journal of clinical investigationMore Details
    22220933 Sudden cardiac death in young adults: environmental risk factors and genetic aspects of premature atherosclerosis.Journal of forensic sciencesMore Details
    22453571 "Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis."JAMA : the journal of the American Medical AssociationMore Details
    22244043 Molecular characterization of familial hypercholesterolemia in Spain.AtherosclerosisMore Details
    21876547 Cholesterol efflux from macrophages is influenced differentially by plasmas from overweight insulin-sensitive and -resistant subjects.International journal of obesity (2005)More Details
    22783321 Coalition of DNA polymorphisms of ApoB and ApoAI genes is related with coronary artery disease in Kazaks.Journal of geriatric cardiology : JGCMore Details
    22500948 "Consistency of extended-release niacin/laropiprant effects on Lp(a), ApoB, non-HDL-C, Apo A1, and ApoB/ApoA1 ratio across patient subgroups.""American journal of cardiovascular drugs : drugs, devices, and other"More Details
    22408029 Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia.European heart journalMore Details
    22911176 Role of lipid apheresis in changing times.Clinical research in cardiology supplementsMore Details
    22224712 Exploring the value of apoB48 as a marker for atherosclerosis in clinical practice.European journal of clinical investigationMore Details
    22228254 Screening for familial hypercholesterolaemia.PathologyMore Details
    22017319 Management of familial hypercholesterolaemia in children and adolescents.Journal of paediatrics and child healthMore Details
    22698793 The molecular basis of familial hypercholesterolemia in the Czech Republic: spectrum of LDLR mutations and genotype-phenotype correlations.AtherosclerosisMore Details
    21913916 Erythrocyte-associated apolipoprotein B and its relationship with clinical and subclinical atherosclerosis.European journal of clinical investigationMore Details
    23130121 Apolipoprotein C-III as a Potential Modulator of the Association Between HDL-Cholesterol and Incident Coronary Heart Disease.Journal of the American Heart AssociationMore Details
    22301884 Antisense inhibition of apoB synthesis with mipomersen reduces plasma apoC-III and apoC-III-containing lipoproteins.Journal of lipid researchMore Details
    23173569 Identification of the HDL-ApoCIII to VLDL-ApoCIII ratio as a predictor of coronary artery disease in the general population: the Chin-Shan Community Cardiovascular Cohort (CCCC) study in Taiwan.Lipids in health and diseaseMore Details
    23028747 Prediction of risk factors for coronary heart disease using Framingham Risk Score in Korean men.PloS oneMore Details
    22479428 Achieving secondary prevention low-density lipoprotein particle concentration goals using lipoprotein cholesterol-based data.PloS oneMore Details
    23067240 Chromosome 1p13 genetic variants antagonize the risk of myocardial infarction associated with high ApoB serum levels.BMC cardiovascular disordersMore Details
    22111029 Premature coronary artery disease and familial hypercholesterolemia: need for early diagnosis and cascade screening in the Indian population.Cardiology research and practiceMore Details
    22834788 Hsp70-2 gene polymorphism: susceptibility implication in Tunisian patients with coronary artery disease.Diagnostic pathologyMore Details
    23226021 Mipomersen and other therapies for the treatment of severe familial hypercholesterolemia.Vascular health and risk managementMore Details
    24175066 Normal levels of inflammatory markers in treated patients with familial hypercholesterolaemia: a cross-sectional study.JRSM cardiovascular diseaseMore Details
    21640348 "Effect of a traditional Mediterranean diet on apolipoproteins B, A-I, and their ratio: a randomized, controlled trial."AtherosclerosisMore Details
    21663566 Determinants of blood levels of some thrombogenic biomarkers in healthy Arab adolescent subjects.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    21986282 Low-density lipoproteins containing apolipoprotein C-III and the risk of coronary heart disease.CirculationMore Details
    22152282 Pitavastatin: novel effects on lipid parameters.Atherosclerosis. SupplementsMore Details
    21889313 Chlamydia pneumoniae heat shock protein 60 is associated with apoptotic signaling pathway in human atheromatous plaques of coronary artery disease patients.Journal of cardiologyMore Details
    21939649 Combined use of high-sensitivity C-reactive protein and apolipoprotein B/apolipoprotein A-1 ratio prior to elective coronary angiography and oral glucose tolerance tests.Clinical biochemistryMore Details
    21862702 "Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk."Journal of lipid researchMore Details
    21394030 Association of the serum apolipoprotein levels with the occurrence of coronary vasospasm.Coronary artery diseaseMore Details
    21310417 An APEX-based genotyping microarray for the screening of 168 mutations associated with familial hypercholesterolemia.AtherosclerosisMore Details
    21532853 Apolipoprotein B is highly associated with the risk of coronary heart disease as estimated by the Framingham risk score in healthy Korean men.Journal of Korean medical scienceMore Details
    21398511 siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids.Journal of lipid researchMore Details
    21860704 Implications of discoveries from genome-wide association studies in current cardiovascular practice.World journal of cardiologyMore Details
    21777740 Non-high-density lipoprotein cholesterol versus apolipoprotein B in cardiovascular risk stratification: do the math.Journal of the American College of CardiologyMore Details
    20223535 Independent and additive predictive value of total cholesterol content of erythrocyte membranes with regard to coronary artery disease clinical presentation.International journal of cardiologyMore Details
    23554700 ApoB/apoA1 is an effective predictor of coronary heart disease risk in overweight and obesity.Journal of biomedical researchMore Details
    21657943 "Familial hypercholesterolemia: epidemiology, Neolithic origins and modern geographic distribution."Critical reviews in clinical laboratory sciencesMore Details
    21257006 Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitus.The American journal of cardiologyMore Details
    20868450 On-treatment lipoprotein components and risk of cerebrovascular events in the Treating to New Targets study.European journal of clinical investigationMore Details
    20708914 Association of apolipoprotein A5 gene polymorphisms and serum lipid levels."Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    21957197 "Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure."Journal of lipid researchMore Details
    24052710 "Role of the APOB Gene Polymorphism (c.12669G>A, p. Gln4154Lys) in Coronary Artery Disease in the Indian Punjabi Population."Balkan journal of medical genetics : BJMGMore Details
    21878044 "Why, when and how should hypertriglyceridemia be treated in the high-risk cardiovascular patient?"Expert review of cardiovascular therapyMore Details
    21484527 Abnormal lipoprotein(a) levels predict coronary artery calcification in Southeast Asians but not in Caucasians: use of noninvasive imaging for evaluation of an emerging risk factor.Journal of cardiovascular translational researchMore Details
    21078622 Conventional and Mendelian randomization analyses suggest no association between lipoprotein(a) and early atherosclerosis: the Young Finns Study.International journal of epidemiologyMore Details
    21117970 Effects of coadministered ezetimibe plus fenofibrate in mixed dyslipidemic patients with metabolic syndrome.Metabolic syndrome and related disordersMore Details
    21247457 Genetic variant of V825I in the ATP-binding cassette transporter A1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations.Lipids in health and diseaseMore Details
    21633520 Cascade Screening for Familial Hypercholesterolemia (FH).PLoS currentsMore Details
    21966218 The effect of the addition of resistance training to a dietary education intervention on apolipoproteins and diet quality in overweight and obese older adults.Clinical interventions in agingMore Details
    21521522 Impact of sphingomyelin levels on coronary heart disease and left ventricular systolic function in humans.Nutrition & metabolismMore Details
    20667056 A multimarker approach for the prediction of coronary artery disease: cost-effectiveness analysis.Value in health : the journal of the International Society for Pharmacoeconomics More Details
    20498921 "APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men.""Molecular medicine (Cambridge, Mass.)"More Details
    20736250 A double heterozygote for familial hypercholesterolaemia and familial defective apolipoprotein B-100.Annals of clinical biochemistryMore Details
    20560981 The effect of fenofibrate on HDL cholesterol and HDL particle concentration in postmenopausal women on tibolone therapy.Clinical endocrinologyMore Details
    20828696 Update of the Portuguese Familial Hypercholesterolaemia Study.AtherosclerosisMore Details
    21059979 Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish.Archives of internal medicineMore Details
    20864672 Genetic variants influencing circulating lipid levels and risk of coronary artery disease."Arteriosclerosis, thrombosis, and vascular biology"More Details
    20019594 Novel mutations identification in exon 4 of LDLR gene in patients with moderate hypercholesterolemia in a Venezuelan population.American journal of therapeuticsMore Details
    20413364 Cardiovascular computed tomographic assessment of the effect of combination lipoprotein therapy on coronary arterial plaque: rationale and design of the AFRICA (Atorvastatin plus Fenofibric acid in the Reduction of Intermediate Coronary Atherosclerosis) study.Journal of cardiovascular computed tomographyMore Details
    20144596 Moderate phenotypic expression of familial hypercholesterolemia in Tunisia.Clinica chimica acta; international journal of clinical chemistryMore Details
    20018285 Pseudoxanthoma elasticum and familial hypercholesterolemia: a deleterious combination of cardiovascular risk factors.AtherosclerosisMore Details
    19800772 Cardiovascular disease prevalence and its relation to risk factors in Alaska Eskimos."Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    20102908 Relation of change in apolipoprotein B/apolipoprotein A-I ratio to coronary plaque regression after Pravastatin treatment in patients with coronary artery disease.The American journal of cardiologyMore Details
    19923980 Impact of genetic polymorphisms on platelet function and aspirin resistance.Blood coagulation & fibrinolysis : an international journal in haemostasis andMore Details
    20152239 "Relation of oxidative biomarkers, vascular dysfunction, and progression of coronary artery calcium."The American journal of cardiologyMore Details
    19965785 Identification of two common variants contributing to serum apolipoprotein B levels in Mexicans."Arteriosclerosis, thrombosis, and vascular biology"More Details
    20715976 Integrated role of two apoliprotein E polymorphisms on apolipoprotein B levels and coronary artery disease in a biethnic population.Metabolic syndrome and related disordersMore Details
    20715933 Apolipoprotein B and non-high-density lipoprotein cholesterol are better risk markers for coronary artery disease than low-density lipoprotein cholesterol in hypertriglyceridemic metabolic syndrome patients.Metabolic syndrome and related disordersMore Details
    20217239 Identification of a recurrent insertion mutation in the LDLR gene in a Pakistani family with autosomal dominant hypercholesterolemia.Molecular biology reportsMore Details
    20842562 Do We Know When and How to Lower Lipoprotein(a)?Current treatment options in cardiovascular medicineMore Details
    20517165 Apolipoprotein C-III gene polymorphism and several environmental factors with serum lipid levels in the Guangxi Hei Yi Zhuang and Han populations.Journal of investigative medicine : the official publication of the AmericanMore Details
    19959168 Changes in the atherogenic profile of patients with type 1 Gaucher disease after miglustat therapy.AtherosclerosisMore Details
    19880117 The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles.AtherosclerosisMore Details
    20334678 PPARgamma gene C161T substitution alters lipid profile in Chinese patients with coronary artery disease and type 2 diabetes mellitus.Cardiovascular diabetologyMore Details
    20395681 High absolute coronary disease risk among Turks: involvement of risk factors additional to conventional ones.CardiologyMore Details
    23105865 Relationship between PON1L55M and Q192R gene polymorphisms and high APO B/APO A-I ratios.Indian journal of clinical biochemistry : IJCBMore Details
    18676970 Concentration of apolipoprotein B is comparable with the apolipoprotein B/apolipoprotein A-I ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality: findings from a multi-ethnic US population.European heart journalMore Details
    19217510 Advanced lipoprotein testing: recommendations based on current evidence.Endocrinology and metabolism clinics of North AmericaMore Details
    19497447 "Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial."Journal of the American College of CardiologyMore Details
    21152377 The common apolipoprotein A-1 polymorphism -75A>G is associated with ethnic differences in recurrent coronary events after recovery from an acute myocardial infarction.Heart internationalMore Details
    19336475 Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.Human molecular geneticsMore Details
    19269283 Association of homocysteine thiolactonase activity and PON1 polymorphisms with the severity of acute coronary syndrome.Clinical biochemistryMore Details
    19252179 ApoE and ApoC-I polymorphisms: association of genotype with cardiovascular disease phenotype in African Americans.Journal of lipid researchMore Details
    19319977 The molecular basis of familial hypercholesterolemia in Lebanon: spectrum of LDLR mutations and role of PCSK9 as a modifier gene.Human mutationMore Details
    19041195 [Familial hypercholesterolemia in Tunisia].Pathologie-biologieMore Details
    18851956 ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment.Biochemical pharmacologyMore Details
    18648394 LDLR promoter variant and exon 14 mutation on the same chromosome are associated with an unusually severe FH phenotype and treatment resistance.European journal of human genetics : EJHGMore Details
    18511055 Glycation of LDL in non-diabetic people: Small dense LDL is preferentially glycated both in vivo and in vitro.AtherosclerosisMore Details
    19155782 The environmental and genetic evidence for the association of hyperlipidemia and hypertension.Journal of hypertensionMore Details
    19642911 Body mass and atherogenic dyslipidemia as major determinants of blood levels of B-type natriuretic peptides in Arab subjects with acute coronary syndromes.Metabolic syndrome and related disordersMore Details
    19501926 The comparison of coronary angiographic profiles between diabetic and nondiabetic patients with coronary artery disease in a Chinese population.Diabetes research and clinical practiceMore Details
    19327776 Congestive heart failure is associated with lipoprotein components in statin-treated patients with coronary heart disease Insights from the Incremental Decrease in End points Through Aggressive Lipid Lowering Trial (IDEAL).AtherosclerosisMore Details
    19491209 Apolipoprotein B but not LDL cholesterol is associated with coronary artery calcification in type 2 diabetic whites.DiabetesMore Details
    19222610 Lipid-altering efficacy of ezetimibe/simvastatin 10/20 mg compared with rosuvastatin 10 mg in high-risk hypercholesterolaemic patients inadequately controlled with prior statin monotherapy - The IN-CROSS study.International journal of clinical practiceMore Details
    21637672 "Effects of APOE, APOB and LDLR variants on serum lipids and lack of association with xanthelasma in individuals from Southeastern Brazil."Genetics and molecular biologyMore Details
    19494537 "Apolipoprotein E, CI and B gene polymorphisms in a sample of patients with coronary heart disease in the Kuwaiti population.""Medical principles and practice : international journal of the Kuwait University,"More Details
    19948027 Plasma PLTP activity is inversely associated with HDL-C levels.Nutrition & metabolismMore Details
    18490703 Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies.Journal of lipid researchMore Details
    18922385 Association of low-density lipoprotein particle size and ratio of different lipoproteins and apolipoproteins with coronary heart disease.Journal of cardiologyMore Details
    17462871 Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease."Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    18325181 High-resolution melting analysis for detection of familial ligand-defective apolipoprotein B-100 mutations.Annals of clinical biochemistryMore Details
    18279815 Evaluation of clinical diagnosis criteria of familial ligand defective apoB 100 and lipoprotein phenotype comparison between LDL receptor gene mutations affecting ligand-binding domain and the R3500Q mutation of the apoB gene in patients from a South European population.Translational research : the journal of laboratory and clinical medicineMore Details
    18096825 Femoral atherosclerosis in heterozygous familial hypercholesterolemia: influence of the genetic defect."Arteriosclerosis, thrombosis, and vascular biology"More Details
    18355452 A novel splice site mutation of the LDL receptor gene in a Tunisian hypercholesterolemic family.Clinica chimica acta; international journal of clinical chemistryMore Details
    18640459 "Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study."LancetMore Details
    18261682 "High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A-I: significance for cardiovascular risk: the IDEAL and EPIC-Norfolk studies."Journal of the American College of CardiologyMore Details
    18193043 Newly identified loci that influence lipid concentrations and risk of coronary artery disease.Nature geneticsMore Details
    19041816 [Decrease ApoB/ApoA-1 ratio and cardiovascular risk improvement: a tadalafil pleiotropic effect? Preliminary study on healthy volunteers].Progres en urologie : journal de l'Association francaise d'urologie et de laMore Details
    18702965 Statin therapy alters the relationship between apolipoprotein B and low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol targets in high-risk patients: the MERCURY II (Measuring Effective Reductions in Cholesterol Using Rosuvastatin) trial.Journal of the American College of CardiologyMore Details
    21291725 "Effect of ezetimibe/simvastatin versus atorvastatin or rosuvastatin on modifying lipid profiles in patients with diabetes, metabolic syndrome, or neither: Results of two subgroup analyses."Journal of clinical lipidologyMore Details
    18221422 Glycemic control in adolescents with type 1 diabetes mellitus improves lipid serum levels and oxidative stress.Pediatric diabetesMore Details
    18333887 The contribution of ApoB and ApoA1 measurements to cardiovascular risk assessment."Diabetes, obesity & metabolism"More Details
    18925970 Taurine reduces the secretion of apolipoprotein B100 and lipids in HepG2 cells.Lipids in health and diseaseMore Details
    18590467 Association of the insertion/deletion gene polymorphism of the apolipoprotein B signal peptide with myocardial infarction in Tunisian patients.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    18254714 5' ins/del and 3' VNTR polymorphisms in the apolipoprotein B gene in relation to lipids and coronary artery disease.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    18598204 "Interactions of lipoprotein(a) with diabetes mellitus, apolipoprotein B and cholesterol enhance the prognostic values for coronary artery disease."Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    18801202 Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease.Lipids in health and diseaseMore Details
    19012525 Aggregation of lipoprotein and inflammatory parameters in families with a history of premature myocardial infarction: the Tallinn myocardial infarction study.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    18609106 Role of the fractalkine receptor CX3CR1 polymorphisms V249I and T280M as risk factors for early-onset coronary artery disease in patients with no classic risk factors.Scandinavian journal of clinical and laboratory investigationMore Details
    17403027 The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk.Annals of human geneticsMore Details
    17094996 Genetic defects causing familial hypercholesterolaemia: identification of deletions and duplications in the LDL-receptor gene and summary of all mutations found in patients attending the Hammersmith Hospital Lipid Clinic.AtherosclerosisMore Details
    18066136 "Modulation of apolipoprotein A1 and B, adiponectin, ghrelin, and growth hormone concentrations by plant sterols and exercise in previously sedentary humans."Canadian journal of physiology and pharmacologyMore Details
    17964036 Beyond low-density lipoprotein cholesterol: defining the role of low-density lipoprotein heterogeneity in coronary artery disease.Journal of the American College of CardiologyMore Details
    17964958 LDLR and ApoB are major genetic causes of autosomal dominant hypercholesterolemia in a Taiwanese population.Journal of the Formosan Medical Association = Taiwan yi zhiMore Details
    17845895 Plasma protein lipofuscin-like fluorophores in men with coronary artery disease treated with statins.Archives of medical researchMore Details
    17719023 Development of new enzyme-linked immunosorbent assay for oxidized lipoprotein(a) by using purified human oxidized lipoprotein(a) autoantibodies as capture antibody.Clinica chimica acta; international journal of clinical chemistryMore Details
    17955342 Hyperlipoproteinaemia(a) is a common cause of autosomal dominant hypercholesterolaemia.Journal of inherited metabolic diseaseMore Details
    17652266 Diabetes and arterial extracellular matrix changes in a porcine model of atherosclerosis.The journal of histochemistry and cytochemistry : official journal of theMore Details
    17698856 Apolipoprotein B and non-high density lipoprotein cholesterol and the risk of coronary heart disease in Chinese.Journal of lipid researchMore Details
    17525004 PON1 activity is inversely related to LDL apoB carbonyl content in patients with coronary artery disease.The Kaohsiung journal of medical sciencesMore Details
    17393220 Postprandial lipemia is modified by the presence of the APOB-516C/T polymorphism in a healthy Caucasian population.LipidsMore Details
    17103149 Quantification of serum apolipoprotein B by infrared spectroscopy.Analytical and bioanalytical chemistryMore Details
    16682089 The applicability of the Asian modified criteria of the metabolic syndrome in the Korean population.International journal of cardiologyMore Details
    16797745 Associations of apolipoprotein B with pulse pressure and glucose in Chinese families with familial combined hyperlipidemia.International journal of cardiologyMore Details
    16730731 Redox-sensitive impairment of porcine coronary artery vasodilation by hypochlorite-modified LDL.AtherosclerosisMore Details
    17227233 MTP inhibition as a treatment for dyslipidaemias: time to deliver or empty promises?Expert opinion on therapeutic targetsMore Details
    17890784 Evidence for a quantitative trait locus affecting low levels of apolipoprotein B and low density lipoprotein on chromosome 10 in Caucasian families.Journal of lipid researchMore Details
    17588826 Establishing the benefit of statins in low-to-moderate--risk primary prevention: the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS).Atherosclerosis. SupplementsMore Details
    16677656 Do allelic variants of the connexin37 1019 gene polymorphism differentially predict for coronary artery disease and myocardial infarction?AtherosclerosisMore Details
    17380167 Mechanisms of disease: genetic causes of familial hypercholesterolemia.Nature clinical practice. Cardiovascular medicineMore Details
    16792510 Molecular genetic testing for familial hypercholesterolemia in the Netherlands: a stepwise screening strategy enhances the mutation detection rate.Genetic testingMore Details
    16949489 "Is plasma oxidized low-density lipoprotein, measured with the widely used antibody 4E6, an independent predictor of coronary heart disease among U.S. men and women?"Journal of the American College of CardiologyMore Details
    16712524 Body composition and the apoB/apoA-I ratio in migrant Asian Indians and white Caucasians in Canada."Clinical science (London, England : 1979)"More Details
    16963013 "Interactions of serum hsCRP with apoB, apoB/AI ratio and some components of metabolic syndrome amplify the predictive values for coronary artery disease."Clinical biochemistryMore Details
    16384561 Efficacy and tolerability of combined treatment with L-carnitine and simvastatin in lowering lipoprotein(a) serum levels in patients with type 2 diabetes mellitus.AtherosclerosisMore Details
    16504986 Apolipoproteins as markers and managers of coronary risk.QJM : monthly journal of the Association of PhysiciansMore Details
    16751940 [Lipid profile and nutrition counseling effects in adolescents with family history of premature coronary artery disease].Arquivos brasileiros de cardiologiaMore Details
    16629854 "Associations between apolipoprotein B, apolipoprotein AI, the apolipoprotein B/AI ratio and coronary heart disease: a literature-based meta-analysis of prospective studies."Journal of internal medicineMore Details
    16389549 "Mutational analysis in UK patients with a clinical diagnosis of familial hypercholesterolaemia: relationship with plasma lipid traits, heart disease risk and utility in relative tracing.""Journal of molecular medicine (Berlin, Germany)"More Details
    19804074 "The effects of apoA-I/C-III/A-IV, apoE and apoB polymorphisms on carotid artery intima-media thickness."Future cardiologyMore Details
    16487434 Short-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects.Clinical endocrinologyMore Details
    16154574 Modulating effects of cholesterol feeding and simvastatin treatment on platelet-activating factor acetylhydrolase activity and lysophosphatidylcholine concentration.AtherosclerosisMore Details
    16752182 Apolipoprotein B: a predictor of inflammatory status in postmenopausal overweight and obese women.DiabetologiaMore Details
    16843720 Fatty acids bound to human serum albumin and its structural variants modulate apolipoprotein B secretion in HepG2 cells.Biochimica et biophysica actaMore Details
    16617174 The Ile128Thr polymorphism influences stability and ligand binding properties of the microsomal triglyceride transfer protein.Journal of lipid researchMore Details
    16461842 Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells.CirculationMore Details
    16322531 Increased apolipoprotein deposits in early atherosclerotic lesions distinguish symptomatic from asymptomatic patients."Arteriosclerosis, thrombosis, and vascular biology"More Details
    17142622 Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk.Journal of medical geneticsMore Details
    17087781 Identification and characterization of novel low-density lipoprotein receptor mutations of familial hypercholesterolaemia patients in Taiwan.European journal of clinical investigationMore Details
    16990559 Relationship between lipid abnormalities and insulin resistance in Japanese school children."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16763159 Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16477380 "Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice."Molecular and cellular biochemistryMore Details
    16396678 Further evaluation of plasma sphingomyelin levels as a risk factor for coronary artery disease.Nutrition & metabolismMore Details
    17032131 Apolipoprotein B gene 3'VNTR polymorphism: association with plasma lipids and coronary heart disease in Han Chinese.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    16879071 "The ratio of apoB/apoAI, apoB and lipoprotein(a) are the best predictors of stable coronary artery disease."Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    16375584 "Serum calcium and phosphorus associate with the occurrence and severity of angiographically documented coronary heart disease, possibly through correlation with atherogenic (apo)lipoproteins."Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    16159606 Genetic screening protocol for familial hypercholesterolemia which includes splicing defects gives an improved mutation detection rate.AtherosclerosisMore Details
    16015283 Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions.European journal of human genetics : EJHGMore Details
    16291017 Pharmacogenomics of statin responsiveness.The American journal of cardiologyMore Details
    16316964 Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in men.CirculationMore Details
    16386541 Effect of apolipoprotein B polymorphism in kidney transplantation.Transplantation proceedingsMore Details
    16266403 The association of mitochondrial DNA 5178 C > a polymorphism with plasma lipid levels among three ethnic groups.Annals of human geneticsMore Details
    15741053 Trans fatty acids alter the lipid composition and size of apoB-100-containing lipoproteins secreted by HepG2 cells.The Journal of nutritional biochemistryMore Details
    16004894 Prognostic value of lipoproteins and their relation to inflammatory markers among patients with coronary artery disease.International journal of cardiologyMore Details
    15690311 ApoC-III bound to apoB-containing lipoproteins increase with insulin resistance in Cherokee Indian youth.Metabolism: clinical and experimentalMore Details
    16195894 Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks.Human geneticsMore Details
    16250003 Update of the molecular basis of familial hypercholesterolemia in The Netherlands.Human mutationMore Details
    15777551 Differences between markers of atherogenic lipoproteins in predicting high cardiovascular risk and subclinical atherosclerosis in asymptomatic men.AtherosclerosisMore Details
    16390683 Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism.Critical reviews in clinical laboratory sciencesMore Details
    15321838 Familial hypercholesterolemia and coronary heart disease: a HuGE association review.American journal of epidemiologyMore Details
    15321837 Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review.American journal of epidemiologyMore Details
    15308601 Lipid disorders and mutations in the APOB gene.Clinical chemistryMore Details
    15099276 Effects of lipids and lipid-lowering therapy on hemostatic factors in patients with myocardial infarction.Journal of thrombosis and haemostasis : JTHMore Details
    15146369 Qualitative effect of fenofibrate and quantitative effect of atorvastatin on LDL profile in combined hyperlipidemia with dense LDL."Experimental and clinical endocrinology & diabetes : official journal, German"More Details
    15121031 Insights from apoB: from better diagnosis & therapy to the Medusa Hypothesis.Atherosclerosis. SupplementsMore Details
    15181078 Low-density lipoprotein particle size and its regulatory factors in school children.The Journal of clinical endocrinology and metabolismMore Details
    15222761 Dioxin alters the human low-density and very low-density lipoprotein structure with evidence for specific quenching of Trp-48 in apolipoprotein C-II.BiochemistryMore Details
    15043507 Evidence for a complex risk profile in obese postmenopausal Turkish women with hypertriglyceridaemia and elevated apolipoprotein B."Clinical science (London, England : 1979)"More Details
    15061377 Isolation of plasma small-dense low-density lipoprotein using a simple air-driven ultracentrifuge and quantification using immunoassay of apolipoprotein B.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    15571826 The apolipoprotein E polymorphism is associated with circulating C-reactive protein (the Ludwigshafen risk and cardiovascular health study).European heart journalMore Details
    15523646 LDL-receptor mutations in Europe.Human mutationMore Details
    15530912 Apolipoprotein B determines risk for recurrent coronary events in postinfarction patients with metabolic syndrome.AtherosclerosisMore Details
    15205217 Circulating oxidized low-density lipoprotein and its association with carotid intima-media thickness in asymptomatic members of familial combined hyperlipidemia families."Arteriosclerosis, thrombosis, and vascular biology"More Details
    15630635 Familial defective apolipoprotein B versus familial hypercholesterolemia: an assessment of risk.Seminars in vascular medicineMore Details
    14729863 "APOA5 gene variants, lipoprotein particle distribution, and progression of coronary heart disease: results from the LOCAT study."Journal of lipid researchMore Details
    15543563 Five polymorphisms in gene candidates for cardiovascular disease in Afro-Brazilian individuals.Journal of clinical laboratory analysisMore Details
    15576296 The apoB/apoA-I ratio is better than the cholesterol ratios to estimate the balance between plasma proatherogenic and antiatherogenic lipoproteins and to predict coronary risk.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    12964943 "Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD."BMC medical geneticsMore Details
    12958176 Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion.FASEB journal : official publication of the Federation of American Societies for More Details
    12897184 "A novel and simple method for quantification of small, dense LDL."Journal of lipid researchMore Details
    12637336 LDL containing apolipoprotein CIII is an independent risk factor for coronary events in diabetic patients."Arteriosclerosis, thrombosis, and vascular biology"More Details
    15030301 Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders.Expert review of cardiovascular therapyMore Details
    12730697 Mutations in PCSK9 cause autosomal dominant hypercholesterolemia.Nature geneticsMore Details
    12835223 Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis.CirculationMore Details
    12709788 ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore.Human geneticsMore Details
    12700893 The association of the R219K polymorphism in the ATP-binding cassette transporter 1 ( ABCA1) gene with coronary heart disease and hyperlipidaemia."Journal of molecular medicine (Berlin, Germany)"More Details
    12890925 Pleiotropy and heterogeneity in the expression of atherogenic lipoproteins: the IRAS Family Study.Human heredityMore Details
    12436350 "Effects of SREBF-1a and SCAP polymorphisms on plasma levels of lipids, severity, progression and regression of coronary atherosclerosis and response to therapy with fluvastatin.""Journal of molecular medicine (Berlin, Germany)"More Details
    11902853 Vitamin C intake and apolipoproteins in a healthy elderly Japanese population.Preventive medicineMore Details
    12378047 "Comparison of the effects of dietary saturated, mono-, and n-6 polyunsaturated fatty acids on blood lipid profile, oxidant stress, prostanoid synthesis and aortic histology in rabbits."Annals of nutrition & metabolismMore Details
    11179013 Use of homozygosity mapping to identify a region on chromosome 1 bearing a defective gene that causes autosomal recessive homozygous hypercholesterolemia in two unrelated families.American journal of human geneticsMore Details
    11230170 A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation.Genome researchMore Details
    11359065 "Population genetic analysis of the genes APOE, APOB(3'VNTR) and ACE in some black and Amerindian communities from Colombia."Human heredityMore Details
    11096445 Hammerhead ribozyme as a therapeutic agent for hyperlipidemia: production of truncated apolipoprotein B and hypolipidemic effects in a dyslipidemia murine model.Human gene therapyMore Details
    10873614 Enhanced secretion of ApoB by transfected HepG2 cells overexpressing fibrinogen.Biochemical and biophysical research communicationsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 41 unique genes interacted with APOB. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    MTTP Two-hybrid9915855 CHD related
    BGN Reconstituted Complex12070165 No
    HSP90B1 Affinity Capture-Western12397072|12397072|9694898 No
    PDIA4 Affinity Capture-Western12397072|12397072|9694898 No
    CALCR Affinity Capture-Western12397072|12397072|9694898 No
    PPIB Affinity Capture-Western12397072|12397072 No
    LIPC Reconstituted Complex9685400 CHD related
    UBC Affinity Capture-Western15618547|18550891|22238364 No
    LRP6 Reconstituted Complex18948618 CHD related
    VCP Affinity Capture-Western18550891|19164805 No
    APOB Affinity Capture-Western19164805 CHD related
    HSPA5 Affinity Capture-Western19164805 No
    SYVN1 Affinity Capture-Western19164805 No
    DERL1 Affinity Capture-Western19164805 No
    SELS Affinity Capture-Western19164805 CHD related
    FAF2 Affinity Capture-Western22238364 No
    CANX Affinity Capture-Western14498830|14498830 No
    SSE1 Biochemical Activity17823116|17823116 No
    SEC61 Affinity Capture-Western17823116 No
    RPT6 Biochemical Activity17823116 No
    KAR2 Biochemical Activity17823116 No
    UFD1 Biochemical Activity17823116 No
    UBC7 Biochemical Activity17823116 No
    SSM4 Biochemical Activity17823116 No
    HRD1 Biochemical Activity17823116 No
    SSA1 Affinity Capture-Western17823116 No
    CALR Affinity Capture-Western10513896|10513896,12397072 No
    SEC61A1 Affinity Capture-Western9565615 No
    SEC61B Affinity Capture-Western9565615|9565615 No
    UCHL5 Affinity Capture-MS21800051 No
    PDI1 Affinity Capture-Western22190736 No
    SUMO2 Affinity Capture-MS21693764 No
    RAD21 Affinity Capture-Western22145905 No
    APOA1 Affinity Capture-Western19164805|7592581 CHD related
    PLIN2 Affinity Capture-Western22238364 No
    HSPA1A in vitro9252351 CHD related
    HSP90AA1 in vitro;in vivo11333259 CHD related
    LRP2 in vitro;in vivo10330424 No
    LDLR in vivo12031600 CHD related
    HSPA8 in vivo9694898 CHD related
    SEC61A2 in vivo9565615 No

    Involved FDA drugs

    There was no drug associated with APOB