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Basic Informations of Hypoxia-inducible factor 1-alpha

Entrez Gene ID: 15251 [Pubmed]

UniProt Protein Name: Hypoxia-inducible factor 1-alpha

UniProt ID: Q61221

Related Drug:

No Related Drugs

References

PMID:16818815|Circulation. 2006;114:150-159
..."Here, we report that endogenous integrin-linked kinase (ILK) is a novel molecule that responds to hypoxia in ECs that regulates the expression of stromal cell-derived factor-1 (SDF-1) and intercellular adhesion molecule-1 (ICAM-1) through nuclear factor-kappaB and hypoxia-inducible factor-1alpha and induces recruitment of EPCs to ischemic areas"...

PMID:17646578|Circulation. 2007;116:774-781
..."Mice carrying significant Phd2 disruption in multiple organs, including the liver, heart, kidney, and lung, displayed excessive vascular growth not only in these organs but also in the brain, where Phd2 disruption was very inefficient. "...

PMID:18040029|Circulation. 2007;116:2818-2829
...Aging impairs EPC trafficking to sites of ischemia through a failure of aged tissues to normally activate the hypoxia-inducible factor 1alpha-mediated hypoxia response....

PMID:20606117|Circulation. 2010;122:282-292
..."An impaired MIF-AMPK activation response in senescence thus may be attributed to an aging-associated defect in hypoxia-inducible factor 1alpha, the transcription factor for MIF. "...

PMID:18591435|Circulation. 2008;118:166-175
..." Finally, selective small interfering RNA repression of prolylhydroxylase 2 resulted in significant activation of HIF-1 alpha and attenuated myocardial infarct sizes (0.44+/-0.09-fold). "...

PMID:19546390|Circulation. 2009;120:50-59
..."Mice with right femoral artery ligation were treated, by in vivo electrotransfer, with plasmids encoding for an irrelevant short hairpin RNA (shRNA) (shCON [control]) or specific shRNAs directed against HIF-1alpha (shHIF-1alpha), PHD1 (shPHD1), PHD2 (shPHD2), and PHD3 (shPHD3). "...

PMID:19652095|Circulation. 2009;120:617-627
... We demonstrated that the increased RGC-32 expression by hypoxia was via hypoxia-inducible factor-1/vascular endothelial growth factor induction in cultured endothelial cells....

[All Refs in Pubmed]

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