Basic Informations of Toll-like receptor 4

Entrez Gene ID: 21898 [Pubmed]

UniProt Protein Name: Toll-like receptor 4

UniProt ID: Q9QUK6

Related Drug:

DrugBank IDDrug Name
DB027673-Hydroxy-Myristic Acid


PMID:16401773|Circulation. 2006;113:258-265
...Activation of interleukin-1 type 1 and Toll-like receptors that share the common downstream adaptor molecule MyD88 is required for disease induction...

PMID:16820585|Circulation. 2006;114[suppl I]:I-270–I-274
...We conclude that inhibition of TLR4 with eritoran in an in situ murine model significantly reduces MI/R injury and markers of an inflammatory response...

PMID:21382888|Circulation. 2011;123:1216-1226
..."In striking contrast, S100A9-deficient dendritic cells showed an exacerbated release of cytokines after toll-like receptor stimulation. "...

PMID:18227389|Circulation. 2008; 117:940-951
..."We show that STAT1 is serine phosphorylated in macrophages subjected to type A scavenger receptor ligands and endoplasmic reticulum stress in a manner requiring cytosolic calcium, calcium/calmodulin-dependent protein kinase II, and toll-like receptor-4. "...

PMID:18852364|Circulation. 2008;118:1837-1847
...The results suggest that high-density lipoprotein and apolipoprotein A-1 exert anti-inflammatory effects by promoting cholesterol efflux via ABCG1 and ABCA1 with consequent attenuation of signaling via Toll-like receptors. ...

PMID:19620505|Circulation. 2009;120:427-436
..."Myeloid-related protein (MRP)-8 (S100A8) and MRP-14 (S100A9) are members of the S100 family of calcium-modulated proteins that regulate myeloid cell function and control inflammation, in part, through activation of Toll-like receptor-4 and the receptor for advanced glycation end products. "...

[All Refs in Pubmed]

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